Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.34 |
| ▸ | SPHK1 | Q9NYA1 | 6/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.31 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.31 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.31 |
| ▸ | MGLL | Q99685 | 3/20 | 0.31 |
| ▸ | FAAH | O00519 | 2/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21695294 | 0.89 | HDAC3 (0.37) | OPRM1OPRD1OPRK1PSEN1PSEN2 | |
| SCHEMBL17813693 | 0.88 | RAB9A (0.36) | OPRM1OPRD1OPRK1PSEN1PSEN2 | |
| SCHEMBL16847844 | 0.87 | OPRM1 (0.33) | OPRM1OPRD1OPRK1 | |
| SCHEMBL17650868 | 0.87 | HDAC3 (0.32) | OPRM1OPRD1OPRK1PSEN1PSEN2 | |
| SCHEMBL17801960 | 0.87 | ITGB1 (0.34) | OPRM1OPRD1OPRK1PSEN1PSEN2 | |
| SCHEMBL21695308 | 0.87 | OPRM1 (0.36) | OPRM1OPRD1OPRK1SPHK1PSEN1 | |
| SCHEMBL22698603 | 0.86 | SIRT2 (0.35) | OPRM1OPRD1OPRK1 | |
| SCHEMBL19683931 | 0.85 | SIRT2 (0.37) | — | |
| SCHEMBL20830828 | 0.85 | SIRT2 (0.34) | OPRM1OPRD1OPRK1 | |
| SCHEMBL28953170 | 0.84 | SIRT2 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10556895-B2 | Quaternary amine compounds and antibody-drug conjugates thereof | GENENTECH, INC. (US) | 2020-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10556895-B2 | Quaternary amine compounds and antibody-drug conjugates thereof | H1-5, H1-4, CD47 | OPRM1 2448/4885OPRD1 4102/4885OPRK1 3424/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.