Sugi Predict

Sugi Predict / Compounds / SCHEMBL2169795

SCHEMBL2169795

SCHEMBL2169795

CC1(C)C(=O)N(C2C3CC4CC(C3)CC2C4)N1C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1

nearest known ligand 0.39

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ HIF1A Q16665 1/20 0.39
▸ TACR1 P25103 5/20 0.37
▸ CYP3A4 P08684 5/20 0.36
▸ USP2 O75604 5/20 0.36
▸ TSHR P16473 4/20 0.36
▸ CYP2C19 P33261 1/20 0.36
▸ CYP2C9 P11712 3/20 0.35
▸ CES2 O00748 1/20 0.35
▸ CYP1A2 P05177 1/20 0.34
▸ CYP2D6 P10635 1/20 0.34
▸ RHOC P08134 1/20 0.34
▸ RHOA P61586 1/20 0.34
▸ HSD17B10 Q99714 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2185159 0.89 LMNA (0.44) CES2
SCHEMBL2169755 0.88 MEN1 (0.39) USP2TSHR
SCHEMBL2169689 0.82 P2RX7 (0.35) USP2TSHRCYP1A2CYP2D6HSD17B10
SCHEMBL2169157 0.80 MEN1 (0.40) USP2
SCHEMBL2170275 0.80 ALDH1A1 (0.40) CYP3A4USP2CYP2C19CYP2C9CYP1A2
SCHEMBL2169090 0.79 USP2 (0.51) USP2TSHR
SCHEMBL2168658 0.78 PLA2G7 (0.41) CYP3A4USP2TSHRCYP2C19CYP2C9
SCHEMBL13368830 0.78 USP2 (0.39) USP2
SCHEMBL2169195 0.78 PKM (0.40) CYP3A4USP2CYP2C19CYP2C9
SCHEMBL2169109 0.77 CYP2C9 (0.38) USP2CYP2C19CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8252781-B2 1,2-diazetidin-3-one derivatives and drugs containing same KOWA COMPANY, LTD. (JP) 2012-08-28 — — US disclosed
US-8252781-B2 1,2-diazetidin-3-one derivatives and drugs containing same KOWA COMPANY, LTD. (JP) 2012-08-28 — — US disclosed
US-8252781-B2 1,2-diazetidin-3-one derivatives and drugs containing same KOWA COMPANY, LTD. (JP) 2012-08-28 — — US disclosed
EP-2348019-A1 1,2-DIAZETIDIN-3-ONE DERIVATIVE AND PHARMACEUTICAL AGENT COMPRISING SAME Kowa Company, Ltd. (JP) 2011-07-27 — — EP disclosed
EP-2348019-A1 1,2-DIAZETIDIN-3-ONE DERIVATIVE AND PHARMACEUTICAL AGENT COMPRISING SAME Kowa Company, Ltd. (JP) 2011-07-27 — — EP disclosed
US-20100144694-A1 1,2-DIAZETIDIN-3-ONE DERIVATIVES AND DRUGS CONTAINING SAME KOWA COMPANY, LTD. (JP) 2010-06-10 — — US disclosed
US-20100144694-A1 1,2-DIAZETIDIN-3-ONE DERIVATIVES AND DRUGS CONTAINING SAME KOWA COMPANY, LTD. (JP) 2010-06-10 — — US disclosed
US-20100144694-A1 1,2-DIAZETIDIN-3-ONE DERIVATIVES AND DRUGS CONTAINING SAME KOWA COMPANY, LTD. (JP) 2010-06-10 — — US disclosed
WO-2010050191-A1 1,2-DIAZETIDIN-3-ONE DERIVATIVE AND PHARMACEUTICAL AGENT COMPRISING SAME 興和株式会社 (JP) 2010-05-06 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100144694-A1 1,2-DIAZETIDIN-3-ONE DERIVATIVES AND DRUGS CONTAINING SAME HSD11B1, HSD11B2, HSD3B1 HIF1A 1845/4885TACR1 1234/4885CYP3A4 271/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.