SCHEMBL21709145

SCHEMBL21709145

C#CCNCC(O)c1cc(C#C)c(OCC#C)c(OCC#C)c1

nearest known ligand 0.36

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 2/20 0.35
MAOA P21397 1/20 0.33
MAOB P27338 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.32
LMNA P02545 1/20 0.30
HTT P42858 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21709164 0.88 KDM1A (0.35) KDM1AMAOAMAOBLMNA
SCHEMBL21709215 0.84 KDM1A (0.30) KDM1A
SCHEMBL21709155 0.82 NFKB1 (0.35) MAOBSMN1; SMN2LMNA
SCHEMBL21709053 0.79 KDM1A (0.40) KDM1AMAOAMAOBLMNA
SCHEMBL21708904 0.78 KDM1A (0.37) KDM1AMAOAMAOB
SCHEMBL21709218 0.78 MAOA (0.31) MAOA
SCHEMBL21709054 0.77 SLC22A3 (0.48) LMNA
SCHEMBL21708891 0.75 KDM1A (0.35) KDM1AMAOAMAOB
SCHEMBL21708879 0.73 ADRB2 (0.43) LMNA
SCHEMBL21709216 0.73 MAOA (0.32) KDM1AMAOAMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020032080-A1 COMPOUND, SALT OF COMPOUND, NEUROMODULATION AGENT, METHOD FOR EVALUATING NEUROMODULATION AGENT, METHOD FOR PRODUCING COMPOUND, AND METHOD FOR PRODUCING SALT OF COMPOUND 学校法人慶應義塾 2020-02-13 WO disclosed