Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 5/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | BRD2 | P25440 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GHSR | Q92847 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | EDNRA | P25101 | 2/20 | 0.37 |
| ▸ | FABP4 | P15090 | 1/20 | 0.37 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.37 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2169949 | 0.84 | ALDH1A1 (0.58) | HTR6ALDH1A1LMNAMEN1HTT | |
| SCHEMBL2169818 | 0.83 | HSD17B2 (0.49) | HTR6ALDH1A1MAPTLMNAHTT | |
| SCHEMBL2170956 | 0.82 | BRD4 (0.41) | HTR6BRD4BRD2MAPTPOLB | |
| SCHEMBL2171141 | 0.81 | HTR6 (0.49) | HTR6BRD4BRD2ALDH1A1GHSR | |
| SCHEMBL2171618 | 0.80 | FFAR1 (0.50) | HTR6ALDH1A1MAPTLMNAMEN1 | |
| SCHEMBL2170713 | 0.79 | L3MBTL1 (0.49) | HTR6BRD4ALDH1A1LMNAHTT | |
| SCHEMBL2171076 | 0.77 | SLC2A1 (0.46) | HTR6ALDH1A1MAPTLMNAHTT | |
| SCHEMBL2550898 | 0.76 | DDB1 (0.36) | BRD4 | |
| Hydrochloric Acid SCHEMBL5983919 | 0.75 | F2R (0.52) | ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL16827668 | 0.75 | NR3C1 (0.45) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346847-A1 | ARYL SULFONAMIDE AMINE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS | Suven Life Sciences Limited (IN) | 2011-07-27 | — | — | EP | claimed |
| WO-2010032258-A1 | ARYL SULFONAMIDE AMINE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS | SUVEN LIFE SCIENCES LIMITED (IN) | 2010-03-25 | — | — | WO | claimed |