Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 6/20 | 0.47 |
| ▸ | HTR6 | P50406 | 3/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | HTR1B | P28222 | 2/20 | 0.46 |
| ▸ | HTR2C | P28335 | 2/20 | 0.46 |
| ▸ | HTR1F | P30939 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2170956 | 0.91 | BRD4 (0.41) | SLC22A12HTR6HTR1AHTR1BHTR2C | |
| SCHEMBL2170067 | 0.88 | CCNT1 (0.50) | HTR6HTR2CMEN1KMT2APGR | |
| Hydrochloric Acid SCHEMBL2169494 | 0.87 | CCNT1 (0.49) | HTR6HTR2CMEN1KMT2APGR | |
| SCHEMBL2170768 | 0.83 | ESR1 (0.45) | HTR6MEN1KMT2APGRALDH1A1 | |
| SCHEMBL2170564 | 0.82 | HSD17B3 (0.48) | HTR6KMT2ABRD4ALDH1A1MAPT | |
| SCHEMBL2170359 | 0.82 | MAPT (0.48) | HTR6MEN1KMT2APGRMAPT | |
| SCHEMBL2171609 | 0.81 | HTR6 (0.46) | HTR6HTR1AHTR1BHTR2CPGR | |
| SCHEMBL2231550 | 0.78 | PPARG (0.49) | HTR6BRD4HTTLMNA | |
| SCHEMBL2171331 | 0.77 | FFAR4 (0.48) | HTR6MAPTLMNA | |
| SCHEMBL2171141 | 0.76 | HTR6 (0.49) | HTR6MEN1KMT2ABRD4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346847-A1 | ARYL SULFONAMIDE AMINE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS | Suven Life Sciences Limited (IN) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010032258-A1 | ARYL SULFONAMIDE AMINE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS | SUVEN LIFE SCIENCES LIMITED (IN) | 2010-03-25 | — | — | WO | disclosed |