Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | CTSG | P08311 | 1/20 | 0.46 |
| ▸ | CMA1 | P23946 | 1/20 | 0.46 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.46 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30753435 | 1.00 | LMNA (0.48) | LMNAMAPTSMN1; SMN2CA12CA1 | |
| SCHEMBL21715451 | 0.89 | CYP4F2 (0.41) | LMNAMAPTSMN1; SMN2CA12CA1 | |
| SCHEMBL30753448 | 0.89 | CYP4F2 (0.41) | LMNAMAPTSMN1; SMN2CA12CA1 | |
| SCHEMBL490337 | 0.89 | CYP4F2 (0.57) | LMNAMAPTSMN1; SMN2CA12CA1 | |
| SCHEMBL21715406 | 0.89 | CA12 (0.51) | CA12CA1CA2CA14ALDH1A1 | |
| SCHEMBL30753439 | 0.89 | CA12 (0.51) | CA12CA1CA2CA14ALDH1A1 | |
| SCHEMBL14721724 | 0.88 | ALDH1A1 (0.48) | LMNAMAPTSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL28873178 | 0.88 | CYP4F2 (0.52) | SMN1; SMN2ALDH1A1KMT2AMEN1CYP4F2 | |
| SCHEMBL21715447 | 0.85 | DRD2 (0.45) | LMNAMAPTSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL30753446 | 0.85 | DRD2 (0.45) | LMNAMAPTSMN1; SMN2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112789035-B | Benzocycloheptene analogues and related compounds having activity as anticancer agents | 贝勒大学 | 2024-02-09 | — | — | CN | disclosed |
| EP-3836910-A1 | BENZOSUBERENE ANALOGUES AND RELATED COMPOUNDS WITH ACTIVITY AS ANTICANCER AGENTS | Baylor University (US) | 2021-06-23 | — | — | EP | disclosed |
| CN-112789035-A | Benzocycloheptene analogs and related compounds having activity as anticancer agents | 贝勒大学 | 2021-05-11 | — | — | CN | disclosed |
| US-10807932-B2 | Benzosuberene analogues and related compounds with activity as anticancer agents | BAYLOR UNIVERSITY (US) | 2020-10-20 | — | — | US | disclosed |
| US-10807932-B2 | Benzosuberene analogues and related compounds with activity as anticancer agents | BAYLOR UNIVERSITY (US) | 2020-10-20 | — | — | US | disclosed |
| WO-2020037209-A1 | BENZOSUBERENE ANALOGUES AND RELATED COMPOUNDS WITH ACTIVITY AS ANTICANCER AGENTS | BAYLOR UNIVERSITY (US) | 2020-02-20 | — | — | WO | disclosed |
| US-20200055805-A1 | BENZOSUBERENE ANALOGUES AND RELATED COMPOUNDS WITH ACTIVITY AS ANTICANCER AGENTS | BAYLOR UNIVERSITY (US) | 2020-02-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200055805-A1 | BENZOSUBERENE ANALOGUES AND RELATED COMPOUNDS WITH ACTIVITY AS ANTICANCER AGENTS | TUBB1, TUBB3, TUBB | LMNA 927/4885MAPT 111/4885SMN1; SMN2 2568/4885 |
| US-10807932-B2 | Benzosuberene analogues and related compounds with activity as anticancer agents | TUBB1, TUBB3, TUBB | LMNA 927/4885MAPT 111/4885SMN1; SMN2 2568/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.