Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1121583 | 0.94 | — | — | |
| Water SCHEMBL27723119 | 0.94 | — | — | |
| SCHEMBL330 | 0.94 | — | — | |
| SCHEMBL18526940 | 0.89 | — | — | |
| SCHEMBL23175203 | 0.88 | CA1 (0.36) | — | |
| SCHEMBL5619594 | 0.88 | — | — | |
| Lithium Ion SCHEMBL7597553 | 0.88 | — | — | |
| Zinc Ion SCHEMBL28120057 | 0.88 | CA1 (0.36) | — | |
| SCHEMBL7664601 | 0.88 | — | — | |
| SCHEMBL1720332 | 0.88 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022149584-A1 | PEPTIDE | ＡＧＣ株式会社 | 2022-07-14 | — | — | WO | disclosed |
| EP-2346836-B1 | PROCESSES FOR THE PREPARATION OF BENDAMUSTINE | CEPHALON INC (US) | 2018-03-07 | — | — | EP | disclosed |
| US-8420829-B2 | Processes for the preparation of bendamustine | CEPHALON, INC. (US) | 2013-04-16 | — | — | US | disclosed |
| US-20110190509-A1 | Processes for the Preparation of Bendamustine | CEPHALON, INC. (US) | 2011-08-04 | — | — | US | disclosed |
| EP-2346836-A1 | PROCESSES FOR THE PREPARATION OF BENDAMUSTINE | Cephalon, Inc. (US) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010042568-A1 | PROCESSES FOR THE PREPARATION OF BENDAMUSTINE | CEPHALON, INC. (US) | 2010-04-15 | — | — | WO | disclosed |