SCHEMBL21751409

SCHEMBL21751409

Nc1cccc(-c2cn3c(=O)c(Cc4ccco4)nc-3c(Cc3ccccc3)[nH]2)c1F

nearest known ligand 0.34

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ ADORA2B P29275 8/20 0.34
▸ ADORA2A P29274 7/20 0.34
▸ PNP P00491 2/20 0.33
▸ LTB4R Q15722 1/20 0.33
▸ TSHR P16473 4/20 0.33
▸ ALDH1A1 P00352 3/20 0.33
▸ LMNA P02545 2/20 0.33
▸ MAPK1 P28482 1/20 0.33
▸ HTT P42858 1/20 0.33
▸ SMN1; SMN2 Q16637 1/20 0.33
▸ KDM4E B2RXH2 1/20 0.33
▸ HPGD P15428 1/20 0.33
▸ ALOX15 P16050 1/20 0.31
▸ HSD17B10 Q99714 1/20 0.31
▸ KMT2A Q03164 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19810261 0.92 LTB4R (0.36) ADORA2BADORA2APNPLTB4RTSHR
SCHEMBL27213500 0.91 ADORA2B (0.35) ADORA2BADORA2ATSHRALDH1A1LMNA
SCHEMBL21751325 0.90 PLA2G7 (0.33) ADORA2BADORA2APNPALDH1A1LMNA
SCHEMBL21751403 0.90 ALDH1A1 (0.34) ADORA2BADORA2ATSHRALDH1A1LMNA
SCHEMBL21751410 0.90 ADORA2B (0.37) ADORA2BADORA2APNPLTB4RTSHR
SCHEMBL25760333 0.90 ADORA2B (0.37) ADORA2BADORA2ATSHRALDH1A1LMNA
SCHEMBL21751330 0.90 ADORA2A (0.36) ADORA2BADORA2APNP
SCHEMBL21751328 0.88 LTB4R (0.36) LTB4R
SCHEMBL20543457 0.88 ADORA2B (0.36) ADORA2BADORA2ATSHRALDH1A1LMNA
SCHEMBL30110598 0.88 ADORA2B (0.36) ADORA2BADORA2ATSHRALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250264464-A1 COMPOSITIONS AND METHODS FOR ANALYTE DETECTION USING BIOLUMINESCENCE PROMEGA CORPORATION 2025-08-21 — — US disclosed
EP-3981839-B1 COELENTERAZINE ANALOGS FOR USE IN LUCIFERASE-BASED ASSAYS PROMEGA CORP (US) 2025-08-20 — — EP disclosed
CN-119955899-A Compositions, methods and kits for stabilizing coelenterazine and analogs and derivatives thereof 普洛麦格公司 2025-05-09 — — CN disclosed
CN-112996923-B Compositions and methods for stabilizing coelenterazine and analogs and derivatives thereof 普洛麦格公司 2025-02-18 — — CN disclosed
US-20240059697-A1 COELENTERAZINE ANALOGUES PROMEGA CORPORATION 2024-02-22 — — US disclosed
US-11691976-B2 Coelenterazine analogues PROMEGA CORPORATION (US) 2023-07-04 — — US disclosed
US-11691976-B2 Coelenterazine analogues PROMEGA CORPORATION (US) 2023-07-04 — — US disclosed
US-11691976-B2 Coelenterazine analogues PROMEGA CORPORATION (US) 2023-07-04 — — US disclosed
US-11534504-B2 Compositions and methods for stabilizing coelenterazine and analogs and derivatives thereof PROMEGA CORPORATION (US) 2022-12-27 — — US disclosed
US-11534504-B2 Compositions and methods for stabilizing coelenterazine and analogs and derivatives thereof PROMEGA CORPORATION (US) 2022-12-27 — — US disclosed
EP-3861128-A2 COMPOSITIONS AND METHODS FOR STABILIZING COELENTERAZINE AND ANALOGS AND DERIVATIVES THEREOF Promega Corporation (US) 2021-08-11 — — EP disclosed
EP-3841173-A1 COELENTERAZINE ANALOGUES Promega Corporation (US) 2021-06-30 — — EP disclosed
US-20200386748-A1 COMPOSITIONS AND METHODS FOR ANALYTE DETECTION USING BIOLUMINESCENCE PROMEGA CORPORATION 2020-12-10 — — US disclosed
US-20200386748-A1 COMPOSITIONS AND METHODS FOR ANALYTE DETECTION USING BIOLUMINESCENCE PROMEGA CORPORATION 2020-12-10 — — US disclosed
WO-2020210658-A1 COMPOSITIONS AND METHODS FOR ANALYTE DETECTION USING BIOLUMINESCENCE PROMEGA CORPORATION (US) 2020-10-15 — — WO disclosed
US-20200109146-A1 COMPOSITIONS AND METHODS FOR STABILIZING COELENTERAZINE AND ANALOGS AND DERIVATIVES THEREOF PROMEGA CORPORATION 2020-04-09 — — US disclosed
WO-2020072775-A2 COMPOSITIONS AND METHODS FOR STABILIZING COELENTERAZINE AND ANALOGS AND DERIVATIVES THEREOF PROMEGA CORPORATION (US) 2020-04-09 — — WO disclosed
US-20200062766-A1 COELENTERAZINE ANALOGUES PROMEGA CORPORATION 2020-02-27 — — US disclosed
WO-2020041579-A1 COELENTERAZINE ANALOGUES PROMEGA CORPORATION (US) 2020-02-27 — — WO disclosed
US-20200062766-A1 COELENTERAZINE ANALOGUES PROMEGA CORPORATION 2020-02-27 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200062766-A1 COELENTERAZINE ANALOGUES GLB1, SI, TCF7L2 ADORA2B 3105/4885ADORA2A 1970/4885PNP 1002/4885
US-11691976-B2 Coelenterazine analogues GLB1, SI, TCF7L2 ADORA2B 3105/4885ADORA2A 1970/4885PNP 1002/4885
US-20240059697-A1 COELENTERAZINE ANALOGUES GLB1, SI, TCF7L2 ADORA2B 3105/4885ADORA2A 1970/4885PNP 1002/4885
US-20200109146-A1 COMPOSITIONS AND METHODS FOR STABILIZING COELENTERAZINE AND ANALOGS AND DERIVATIVES THEREOF SI, CHLSN, APC ADORA2B 3963/4885ADORA2A 1444/4885PNP 1475/4885
US-11534504-B2 Compositions and methods for stabilizing coelenterazine and analogs and derivatives thereof SI, CHLSN, APC ADORA2B 3963/4885ADORA2A 1444/4885PNP 1475/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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