SCHEMBL21752926

SCHEMBL21752926

FC(F)(F)C1(c2ccc(Oc3ccc(C45CC6CC(CC(C6)C4)C5)cc3)cc2)CC1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 5/20 0.46
KMT2A Q03164 5/20 0.46
LMNA P02545 4/20 0.46
ALDH1A1 P00352 2/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
RAB9A P51151 1/20 0.43
EPHX2 P34913 3/20 0.39
GAA P10253 2/20 0.38
POLB P06746 1/20 0.38
GFER P55789 1/20 0.38
NPC1 O15118 1/20 0.37
NCOA3 Q9Y6Q9 1/20 0.36
MDH1 P40925 1/20 0.36
MDH2 P40926 1/20 0.36
CASP2 P42575 1/20 0.36
HIF1A Q16665 4/20 0.36
EPAS1 Q99814 4/20 0.36
MAPT P10636 1/20 0.35
HTT P42858 2/20 0.35
RAD52 P43351 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21765281 0.84 EPHX2 (0.33) MEN1KMT2ALMNAALDH1A1L3MBTL1
SCHEMBL27845478 0.83 LMNA (0.61) MEN1KMT2ALMNAALDH1A1L3MBTL1
SCHEMBL21765283 0.81 KDM4C (0.33) EPHX2KDM4C
SCHEMBL15055320 0.76 ALDH1A1 (0.79) MEN1KMT2ALMNAALDH1A1L3MBTL1
SCHEMBL19638852 0.76 ALDH1A1 (0.79) MEN1KMT2ALMNAALDH1A1L3MBTL1
SCHEMBL21752967 0.76 LMNA (0.52) MEN1KMT2ALMNAALDH1A1L3MBTL1
SCHEMBL16216731 0.76 LMNA (0.52) MEN1KMT2ALMNAALDH1A1L3MBTL1
SCHEMBL21752924 0.75 MEN1 (0.44) MEN1KMT2ALMNAALDH1A1L3MBTL1
SCHEMBL21752960 0.75 MEN1 (0.50) MEN1KMT2ALMNAALDH1A1L3MBTL1
SCHEMBL16628067 0.74 MDH1 (0.45) MEN1KMT2ALMNAALDH1A1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230141913-A2 PHENOXY(HETERO)ARYL ETHERS OF ANTIPROLIFERACTIVE ACTIVITY Xeniopro GmbH (DE) 2023-05-11 US disclosed
US-20230141913-A2 PHENOXY(HETERO)ARYL ETHERS OF ANTIPROLIFERACTIVE ACTIVITY Xeniopro GmbH (DE) 2023-05-11 US disclosed
US-20230141913-A2 PHENOXY(HETERO)ARYL ETHERS OF ANTIPROLIFERACTIVE ACTIVITY Xeniopro GmbH (DE) 2023-05-11 US disclosed
EP-3841091-A1 PHENOXY(HETERO)ARYL ETHERS OF ANTIPROLIFERATIVE ACTIVITY Xeniopro GmbH (DE) 2021-06-30 EP disclosed
CN-112930337-A Antiproliferative phenoxy (hetero) aryl ethers 赛尼欧普罗有限责任公司 2021-06-08 CN disclosed
WO-2020039094-A1 PHENOXY(HETERO)ARYL ETHERS OF ANTIPROLIFERATIVE ACTIVITY Xeniopro GmbH (DE) 2020-02-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230141913-A2 PHENOXY(HETERO)ARYL ETHERS OF ANTIPROLIFERACTIVE ACTIVITY AHR, MUSK, TYR MEN1 4794/4885KMT2A 762/4885LMNA 2488/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.