Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 10/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 9/20 | 0.42 |
| ▸ | TSHR | P16473 | 8/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 8/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.42 |
| ▸ | LMNA | P02545 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.41 |
| ▸ | CTSL | P07711 | 4/20 | 0.41 |
| ▸ | CTSB | P07858 | 4/20 | 0.41 |
| ▸ | CTSS | P25774 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19920812 | 0.81 | LMNA (0.44) | CYP3A4CYP2C9TSHRCYP2C19ALDH1A1 | |
| SCHEMBL19920764 | 0.77 | CTSB (0.48) | CYP3A4TSHRALDH1A1LMNAMEN1 | |
| SCHEMBL19900624 | 0.75 | CTSS (0.50) | TSHRALDH1A1LMNASMN1; SMN2CTSL | |
| SCHEMBL19900776 | 0.74 | CTSB (0.50) | CYP3A4CYP2C9TSHRCYP2C19ALDH1A1 | |
| SCHEMBL19920827 | 0.73 | CTSB (0.49) | TSHRALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL28293240 | 0.73 | ALDH1A1 (0.49) | TSHRALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL29857191 | 0.73 | CTSS (0.48) | TSHRALDH1A1LMNASMN1; SMN2CTSL | |
| SCHEMBL19920769 | 0.73 | CTSL (0.46) | TSHRALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL19920814 | 0.73 | LMNA (0.43) | ALDH1A1LMNASMN1; SMN2CTSLCTSB | |
| SCHEMBL29420342 | 0.72 | CTSL (0.50) | CYP3A4CYP2C9TSHRCYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10874640-B2 | Substituted pyrrolizine compounds and uses thereof | GILEAD SCIENCES, INC. (US) | 2020-12-29 | — | — | US | disclosed |
| US-20200061024-A1 | SUBSTITUTED PYRROLIZINE COMPOUNDS AND USES THEREOF | GILEAD SCIENCES, INC. | 2020-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200061024-A1 | SUBSTITUTED PYRROLIZINE COMPOUNDS AND USES THEREOF | HMBS, DHFR, HCCS | CYP3A4 218/4885CYP2C9 970/4885TSHR 4242/4885 |
| US-10874640-B2 | Substituted pyrrolizine compounds and uses thereof | HMBS, DHFR, HCCS | CYP3A4 218/4885CYP2C9 970/4885TSHR 4242/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.