Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | QDPR | P09417 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3039898 | 0.81 | CA12 (0.46) | ALDH1A1SMN1; SMN2NPC1ALOX15RAB9A | |
| SCHEMBL21767846 | 0.78 | NAMPT (0.52) | NAMPTKMT2A | |
| SCHEMBL21381860 | 0.77 | ERCC5 (0.42) | NAMPT | |
| SCHEMBL610260 | 0.76 | ALDH1A1 (0.49) | NAMPTALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL8163530 | 0.75 | ALDH1A1 (0.49) | QDPRALDH1A1SMN1; SMN2NPC1ALOX15 | |
| SCHEMBL14496802 | 0.74 | QDPR (0.70) | NAMPTQDPRALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL21767855 | 0.72 | NCOA1 (0.46) | NAMPTALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL17107402 | 0.72 | ENPP2 (0.36) | KCNH2MAPTS1PR5 | |
| SCHEMBL17107406 | 0.72 | ENPP2 (0.36) | KCNH2MAPTS1PR5 | |
| SCHEMBL20140921 | 0.71 | HTR1A (0.45) | RAB9AKCNH2KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10919891-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2021-02-16 | — | — | US | disclosed |
| US-10875862-B2 | — | — | 2020-12-29 | — | — | US | disclosed |
| US-20200131174-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2020-04-30 | — | — | US | disclosed |
| EP-3617209-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2020-03-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10919891-B2 | Heterocyclic compound | CASR, AGTR2, AGTR1 | NAMPT 3149/4885QDPR 605/4885ALDH1A1 3347/4885 |
| US-20200131174-A1 | HETEROCYCLIC COMPOUND | CASR, AGTR2, AGTR1 | NAMPT 3149/4885QDPR 605/4885ALDH1A1 3347/4885 |
| US-10875862-B2 | — | CASR, AGTR2, AGTR1 | NAMPT 3820/4885QDPR 893/4885ALDH1A1 3567/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.