Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.44 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.44 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.36 |
| ▸ | TGM2 | P21980 | 4/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10385511 | 0.96 | ALDH1A1 (0.46) | TSHRALDH1A1MAPK1TDP1ZDHHC20 | |
| SCHEMBL31296560 | 0.96 | ALDH1A1 (0.46) | TSHRALDH1A1MAPK1TDP1ZDHHC20 | |
| Potassium Ion SCHEMBL28961631 | 0.89 | ZDHHC20 (0.50) | TSHRALDH1A1MAPK1TDP1ZDHHC20 | |
| SCHEMBL9639404 | 0.85 | ZDHHC20 (0.50) | TSHRALDH1A1MAPK1TDP1ZDHHC20 | |
| SCHEMBL31296562 | 0.85 | ZDHHC20 (0.50) | TSHRALDH1A1MAPK1TDP1ZDHHC20 | |
| Lithium Ion SCHEMBL21777547 | 0.85 | ZDHHC20 (0.50) | TSHRALDH1A1MAPK1TDP1ZDHHC20 | |
| SCHEMBL28598554 | 0.82 | ZDHHC20 (0.56) | TSHRALDH1A1MAPK1TDP1ZDHHC20 | |
| SCHEMBL29257466 | 0.82 | ZDHHC20 (0.56) | TSHRALDH1A1MAPK1TDP1ZDHHC20 | |
| SCHEMBL10902933 | 0.81 | TSHR (0.52) | TSHRALDH1A1MAPK1TDP1ZDHHC20 | |
| Potassium Ion SCHEMBL3662730 | 0.79 | TSHR (0.50) | TSHRALDH1A1MAPK1TDP1ZDHHC20 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250032398-A1 | HIGH MOLECULAR WEIGHT BLOCK COPOLYMERS COMPRISING REPEATING UNITS DERIVED FROM MONOMERS COMPRISING LACTAM AND ACRYLOYL MOIETIES AND HYDROPHILIC MONOMERS, COMPOSITIONS, AND APPLICATIONS THEREOF | ISP INVESTMENTS LLC (US) | 2025-01-30 | — | — | US | disclosed |
| WO-2020045648-A1 | STATIONARY PHASE FOR CHROMATOGRAPHY | 株式会社ダイセル | 2020-03-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250032398-A1 | HIGH MOLECULAR WEIGHT BLOCK COPOLYMERS COMPRISING REPEATING UNITS DERIVED FROM MONOMERS COMPRISING LACTAM AND ACRYLOYL MOIETIES AND HYDROPHILIC MONOMERS, COMPOSITIONS, AND APPLICATIONS THEREOF | PCNA, ADSL, APH1B | TSHR 3587/4885ALDH1A1 2371/4885MAPK1 4638/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.