Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | MLNR | O43193 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21004687 | 0.80 | LMNA (0.46) | ALDH1A1LMNAHTT | |
| Hydrochloric Acid SCHEMBL20511341 | 0.79 | LMNA (0.46) | ALDH1A1LMNAHTT | |
| SCHEMBL21005028 | 0.78 | PSEN1 (0.46) | POLBKDM4E | |
| Hydrochloric Acid SCHEMBL30437494 | 0.76 | PSEN1 (0.46) | POLBKDM4E | |
| SCHEMBL25771124 | 0.76 | LMNA (0.46) | ALDH1A1LMNAHTTPTGDR2 | |
| Hydrochloric Acid SCHEMBL20511356 | 0.76 | PSEN1 (0.46) | POLBKDM4E | |
| SCHEMBL23887020 | 0.75 | TRPA1 (0.34) | ALDH1A1LMNAPOLBTSHRHTT | |
| SCHEMBL30370975 | 0.75 | TRPA1 (0.34) | ALDH1A1LMNAPOLBTSHRHTT | |
| SCHEMBL20003539 | 0.70 | ALDH1A1 (0.46) | ALDH1A1PTGDRKDM4EGAACHRNA7 | |
| SCHEMBL21834072 | 0.70 | PKM (0.53) | ALDH1A1LMNAPOLBTSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200069643-A1 | PYRROLOPYRROLE COMPOSITIONS AS PYRUVATE KINASE (PKR) ACTIVATORS | NOVO NORDISK HEALTH CARE AG, (CH) | 2020-03-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200069643-A1 | PYRROLOPYRROLE COMPOSITIONS AS PYRUVATE KINASE (PKR) ACTIVATORS | PDK1, PKM, PKLR | ALDH1A1 2884/4885LMNA 1753/4885POLB 1822/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.