Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | RBP4 | P02753 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.30 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.30 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21784698 | 0.79 | LMNA (0.55) | LMNAGAARBP4KDM4EALDH1A1 | |
| SCHEMBL7798825 | 0.70 | CYP3A4 (0.53) | LMNAGAAKDM4EALDH1A1KMT2A | |
| SCHEMBL28068538 | 0.65 | PTGDR2 (0.36) | NOTUMRBP4MEN1KMT2APTGDR2 | |
| SCHEMBL21784784 | 0.65 | MMP2 (0.42) | LMNAKDM4EALDH1A1PTGDR2ADRA2A | |
| SCHEMBL12137589 | 0.65 | LMNA (0.58) | LMNAGAAKDM4EALDH1A1MEN1 | |
| SCHEMBL627928 | 0.65 | LMNA (0.58) | LMNAGAAKDM4EALDH1A1MEN1 | |
| SCHEMBL622694 | 0.65 | LMNA (0.58) | LMNAGAAKDM4EALDH1A1MEN1 | |
| SCHEMBL3728983 | 0.65 | LMNA (0.58) | LMNAGAAKDM4EALDH1A1MEN1 | |
| SCHEMBL21780647 | 0.62 | LMNA (0.43) | LMNAGAARBP4KDM4E | |
| SCHEMBL4680009 | 0.62 | MEN1 (0.46) | RBP4KDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020047239-A1 | INHIBITING αV β6 INTEGRIN | MORPHIC THERAPEUTIC, INC. (US) | 2020-03-05 | — | — | WO | disclosed |