Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.46 |
| ▸ | TYMS | P04818 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | NOS1 | P29475 | 7/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | POLA1 | P09884 | 1/20 | 0.35 |
| ▸ | POLG | P54098 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL609951 | 0.93 | AKR1B1 (0.49) | POLBAKR1B1TYMSHSD17B10KDM4E | |
| SCHEMBL16058737 | 0.93 | AKR1B1 (0.49) | POLBAKR1B1TYMSHSD17B10KDM4E | |
| SCHEMBL29619286 | 0.79 | TYMS (0.66) | POLBAKR1B1TYMSHSD17B10KDM4E | |
| SCHEMBL5665622 | 0.79 | TYMS (0.66) | POLBAKR1B1TYMSHSD17B10KDM4E | |
| SCHEMBL16681740 | 0.79 | AKR1B1 (0.51) | POLBAKR1B1TYMSHSD17B10KDM4E | |
| SCHEMBL17811602 | 0.76 | AKR1B1 (0.45) | POLBAKR1B1TYMSHSD17B10KDM4E | |
| Folic Acid SCHEMBL8897352 | 0.75 | TYMS (0.80) | POLBAKR1B1TYMSHSD17B10KDM4E | |
| Pyrophosphoric Acid SCHEMBL30002402 | 0.73 | TYMS (0.74) | POLBAKR1B1TYMSHSD17B10KDM4E | |
| SCHEMBL3980437 | 0.72 | AKR1B1 (0.47) | POLBAKR1B1TYMSHSD17B10KDM4E | |
| SCHEMBL7639622 | 0.72 | AKR1B1 (0.46) | POLBAKR1B1TYMSHSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220296594-A1 | POTENTIATORS OF ANTIMICROBIAL AND/OR ANTIVIRAL AGENTS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2022-09-22 | — | — | US | disclosed |
| WO-2020227530-A1 | POTENTIATORS OF ANTIMICROBIAL AND/OR ANTIVIRAL AGENTS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2020-11-12 | — | — | WO | disclosed |
| US-20170246226-A1 | COMPOSITIONS AND METHOD FOR TREATMENT AND PROPHYLAXIS OF INFLAMMATORY BOWEL DISEASE | TRACHTMAN IRA MILTON (US) | 2017-08-31 | — | — | US | disclosed |
| US-9649348-B2 | Compositions and method for treatment and prophylaxis of inflammatory bowel disease | TRACHTMAN IRA MILTON (US) | 2017-05-16 | — | — | US | disclosed |
| US-20170056456-A1 | COMPOSITIONS AND METHOD FOR TREATMENT AND PROPHYLAXIS OF INFLAMMATORY BOWEL DISEASE | TRACHTMAN IRA MILTON (US) | 2017-03-02 | — | — | US | disclosed |
| US-9492488-B2 | Compositions and method for treatment and prophylaxis of inflammatory bowel disease | TRACHTMAN IRA MILTON (US) | 2016-11-15 | — | — | US | disclosed |
| US-20160000839-A1 | COMPOSITIONS AND METHOD FOR TREATMENT AND PROPHYLAXIS OF INFLAMMATORY BOWEL DISEASE | TRACHTMAN IRA MILTON (US) | 2016-01-07 | — | — | US | disclosed |
| US-9138441-B2 | Compositions and method for treatment and prophylaxis of inflammatory bowel disease | TRACHTMAN IRA MILTON (US) | 2015-09-22 | — | — | US | disclosed |
| EP-2519108-A1 | COMPOSITIONS AND METHOD FOR TREATMENT AND PROPHYLAXIS OF INFLAMMATORY BOWEL DISEASE | Trachtman, Ira Milton (US) | 2012-11-07 | — | — | EP | disclosed |
| US-20120276201-A1 | COMPOSITIONS AND METHOD FOR TREATMENT AND PROPHYLAXIS OF INFLAMMATORY BOWEL DISEASE | TRACHTMAN IRA MILTON (US) | 2012-11-01 | — | — | US | disclosed |
| WO-2011082218-A1 | COMPOSITIONS AND METHOD FOR TREATMENT AND PROPHYLAXIS OF INFLAMMATORY BOWEL DISEASE | TRACHTMAN IRA MILTON (US) | 2011-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120276201-A1 | COMPOSITIONS AND METHOD FOR TREATMENT AND PROPHYLAXIS OF INFLAMMATORY BOWEL DISEASE | TPMT, NOD2, SI | POLB 2030/4885AKR1B1 1982/4885TYMS 2620/4885 |
| US-20220296594-A1 | POTENTIATORS OF ANTIMICROBIAL AND/OR ANTIVIRAL AGENTS | MAVS, IRF3, STING1 | POLB 45/4885AKR1B1 4216/4885TYMS 72/4885 |
| US-20170056456-A1 | COMPOSITIONS AND METHOD FOR TREATMENT AND PROPHYLAXIS OF INFLAMMATORY BOWEL DISEASE | TPMT, NOD2, SI | POLB 2030/4885AKR1B1 1982/4885TYMS 2620/4885 |
| US-20160000839-A1 | COMPOSITIONS AND METHOD FOR TREATMENT AND PROPHYLAXIS OF INFLAMMATORY BOWEL DISEASE | TPMT, NOD2, SI | POLB 2030/4885AKR1B1 1982/4885TYMS 2620/4885 |
| US-20170246226-A1 | COMPOSITIONS AND METHOD FOR TREATMENT AND PROPHYLAXIS OF INFLAMMATORY BOWEL DISEASE | TPMT, NOD2, SI | POLB 2030/4885AKR1B1 1982/4885TYMS 2620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.