Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | GABRP | O00591 | 2/20 | 0.36 |
| ▸ | GABRD | O14764 | 2/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.36 |
| ▸ | GABRE | P78334 | 2/20 | 0.36 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.36 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.36 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.36 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.36 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.36 |
| ▸ | GRIK1 | P39086 | 5/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17810229 | 1.00 | ALDH1A1 (0.48) | ALDH1A1TDP1GABRPGABRDGABRA1 | |
| SCHEMBL25836557 | 1.00 | ALDH1A1 (0.48) | ALDH1A1TDP1GABRPGABRDGABRA1 | |
| SCHEMBL24983982 | 0.82 | ALDH1A1 (0.41) | ALDH1A1TDP1GABRPGABRDGABRA1 | |
| SCHEMBL18401003 | 0.81 | GRIK1 (0.35) | ALDH1A1TDP1GABRPGABRDGABRA1 | |
| SCHEMBL16018408 | 0.80 | GABRP (0.36) | ALDH1A1TDP1GABRPGABRDGABRA1 | |
| SCHEMBL4397917 | 0.80 | GABRP (0.46) | TDP1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL13050663 | 0.80 | GABRP (0.36) | ALDH1A1TDP1GABRPGABRDGABRA1 | |
| SCHEMBL10212359 | 0.80 | GABRP (0.46) | TDP1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL12132308 | 0.80 | GABRP (0.46) | TDP1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL10140608 | 0.80 | GABRP (0.36) | ALDH1A1TDP1GABRPGABRDGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230322743-A1 | NOVEL SAFRYLAMINE DERIVATIVES HAVING PRODRUG PROPERTIES | MIHKAL GMBH (CH) | 2023-10-12 | — | — | US | disclosed |
| US-20230135635-A1 | INHIBITORS OF ULK1/2 AND METHODS OF USING SAME | Sanford Burnham Prebys Medical Discovery Institute | 2023-05-04 | — | — | US | disclosed |
| US-20210300874-A1 | ISOQUINOLINE-STEROID CONJUGATES AND USES THEREOF | ALCON INC. (CH) | 2021-09-30 | — | — | US | disclosed |
| US-10905766-B2 | Therapeutic compositions and methods for treatment of muscle wasting diseases | OREGON STATE UNIVERSITY (US) | 2021-02-02 | — | — | US | disclosed |
| WO-2020047496-A1 | ISOQUINOLINE-STEROID CONJUGATES AND USES THEREOF | AERIE PHARMACEUTICALS, INC. (US) | 2020-03-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230135635-A1 | INHIBITORS OF ULK1/2 AND METHODS OF USING SAME | ULK2, ULK1, ULK3 | ALDH1A1 4012/4885TDP1 607/4885GABRP 3219/4885 |
| US-10905766-B2 | Therapeutic compositions and methods for treatment of muscle wasting diseases | TNNC1, PYGM, MYLK2 | ALDH1A1 4503/4885TDP1 824/4885GABRP 1778/4885 |
| US-20230322743-A1 | NOVEL SAFRYLAMINE DERIVATIVES HAVING PRODRUG PROPERTIES | HTR2A, HTR2C, HTR1D | ALDH1A1 370/4885TDP1 990/4885GABRP 983/4885 |
| US-20210300874-A1 | ISOQUINOLINE-STEROID CONJUGATES AND USES THEREOF | GRK1, TNK2, CYP11B2 | ALDH1A1 2571/4885TDP1 1729/4885GABRP 2333/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.