Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | SLC34A2 | O95436 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20083990 | 0.90 | LMNA (0.49) | SMN1; SMN2LMNATSHRMEN1KMT2A | |
| SCHEMBL15276906 | 0.90 | SIRT2 (0.52) | SMN1; SMN2LMNATSHRMEN1KMT2A | |
| SCHEMBL15276910 | 0.87 | HTR2B (0.56) | SMN1; SMN2LMNATSHRMEN1KMT2A | |
| SCHEMBL15276907 | 0.85 | SLC6A9 (0.46) | SMN1; SMN2LMNATSHRMEN1KMT2A | |
| SCHEMBL15276904 | 0.84 | MAPT (0.52) | SMN1; SMN2LMNATSHRMEN1KMT2A | |
| SCHEMBL15276909 | 0.83 | RAB9A (0.50) | SMN1; SMN2LMNATSHRMEN1KMT2A | |
| SCHEMBL15276908 | 0.83 | ALDH1A1 (0.44) | SMN1; SMN2LMNATSHRMEN1KMT2A | |
| SCHEMBL21844908 | 0.76 | KDM1A (0.48) | SMN1; SMN2LMNATSHRMEN1KMT2A | |
| SCHEMBL30926944 | 0.75 | SIRT2 (0.80) | SMN1; SMN2LMNAMEN1KMT2ASIRT2 | |
| SCHEMBL27179454 | 0.75 | SIRT2 (0.80) | SMN1; SMN2LMNAMEN1KMT2ASIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3312160-B1 | HEPATITIS B ANTIVIRAL AGENTS | NOVIRA THERAPEUTICS INC (US) | 2020-03-18 | — | — | EP | disclosed |