Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | GRM5 | P41594 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | NAMPT | P43490 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25328235 | 0.80 | THRB (0.77) | KMT2ASMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL9339184 | 0.78 | SMN1; SMN2 (0.56) | KMT2ASMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL17822214 | 0.77 | EPHX2 (0.75) | KMT2ASMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL9809561 | 0.77 | RAB9A (0.76) | KMT2ASMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL25214421 | 0.76 | POLB (0.78) | KMT2AMEN1GAATHRBALDH1A1 | |
| SCHEMBL1609678 | 0.76 | SMN1; SMN2 (0.62) | KMT2ASMN1; SMN2NPC1RAB9AGAA | |
| SCHEMBL15477410 | 0.76 | SMN1; SMN2 (0.66) | KMT2ASMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL31722013 | 0.75 | HTR1A (0.58) | KMT2ASMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL62572 | 0.75 | THRB (0.75) | KMT2ASMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL1388180 | 0.75 | THRB (0.70) | KMT2ASMN1; SMN2NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11324731-B2 | TXNIP-TRX complex inhibitors and methods of using the same | CITY OF HOPE (US) | 2022-05-10 | — | — | US | disclosed |
| US-20200085800-A1 | TXNIP-TRX COMPLEX INHIBITORS AND METHODS OF USING THE SAME | CITY OF HOPE | 2020-03-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11324731-B2 | TXNIP-TRX complex inhibitors and methods of using the same | TXN, TXN2, TXNRD3 | KMT2A 3189/4885SMN1; SMN2 3405/4885NPC1 3649/4885 |
| US-20200085800-A1 | TXNIP-TRX COMPLEX INHIBITORS AND METHODS OF USING THE SAME | TXN, TXN2, TXNRD3 | KMT2A 3189/4885SMN1; SMN2 3405/4885NPC1 3649/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.