Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | RHOA | P61586 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 2/20 | 0.35 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.35 |
| ▸ | CCR6 | P51684 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21856357 | 0.89 | RHOC (0.40) | EPHX2KMT2ARHOAUBE2MDCUN1D1 | |
| SCHEMBL21856326 | 0.83 | RHOC (0.42) | HDAC3HDAC1HDAC2HDAC6RHOA | |
| SCHEMBL21856314 | 0.80 | DDR1 (0.39) | BRAFALDH1A1 | |
| SCHEMBL21856323 | 0.80 | IDH2 (0.45) | EPHX2KMT2AUBE2MDCUN1D1 | |
| SCHEMBL21856349 | 0.79 | DDB1 (0.47) | KMT2AALDH1A1MAPTCYP1A2CYP3A4 | |
| SCHEMBL21856354 | 0.79 | EGFR (0.39) | RHOABRAFCYP3A4CYP2C9 | |
| SCHEMBL21856365 | 0.78 | BRAF (0.36) | RHOABRAF | |
| SCHEMBL21958156 | 0.77 | TEAD1 (0.53) | EPHX2GFERKMT2A | |
| SCHEMBL21856343 | 0.75 | TAS2R14 (0.37) | KMT2ANPSR1UBE2MDCUN1D1 | |
| SCHEMBL21856309 | 0.70 | SPR (0.43) | CCR6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081572-A1 | TRANSCRIPTIONAL ENHANCED ASSOCIATE DOMAIN (TEAD) TRANSCRIPTION FACTOR INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-04-23 | — | — | WO | disclosed |