Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHOC | P08134 | 2/20 | 0.40 |
| ▸ | RHOA | P61586 | 2/20 | 0.40 |
| ▸ | CXCR3 | P49682 | 4/20 | 0.34 |
| ▸ | PAK1 | Q13153 | 3/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | PAK3 | O75914 | 1/20 | 0.34 |
| ▸ | PAK2 | Q13177 | 1/20 | 0.34 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.33 |
| ▸ | IDH2 | P48735 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA4 | P22748 | 2/20 | 0.33 |
| ▸ | CA7 | P43166 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | UBE2M | P61081 | 2/20 | 0.33 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21856326 | 0.92 | RHOC (0.42) | RHOCRHOACSF1RUBE2MDCUN1D1 | |
| SCHEMBL21856348 | 0.89 | PABPC1 (0.40) | RHOAUBE2MDCUN1D1EPHX2KMT2A | |
| SCHEMBL21856323 | 0.88 | IDH2 (0.45) | TEAD1IDH2UBE2MDCUN1D1EPHX2 | |
| SCHEMBL21856354 | 0.87 | EGFR (0.39) | RHOCRHOAIDH2 | |
| SCHEMBL21856314 | 0.86 | DDR1 (0.39) | CSF1RIDH2 | |
| SCHEMBL21856365 | 0.83 | BRAF (0.36) | RHOCRHOACXCR3CSF1R | |
| SCHEMBL21856343 | 0.80 | TAS2R14 (0.37) | CSF1RTEAD1IDH2UBE2MDCUN1D1 | |
| SCHEMBL21856319 | 0.80 | ALDH1A1 (0.42) | UBE2MDCUN1D1MEN1KMT2A | |
| SCHEMBL21856309 | 0.77 | SPR (0.43) | CA12CA1CA2CA4CA7 | |
| SCHEMBL21959807 | 0.75 | IDH2 (0.47) | TEAD1IDH2UBE2MDCUN1D1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081572-A1 | TRANSCRIPTIONAL ENHANCED ASSOCIATE DOMAIN (TEAD) TRANSCRIPTION FACTOR INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-04-23 | — | — | WO | disclosed |