Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 2/20 | 0.47 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KCNT1 | Q5JUK3 | 1/20 | 0.40 |
| ▸ | KCNT2 | Q6UVM3 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21856343 | 0.86 | TAS2R14 (0.37) | KMT2AFFAR4MAPK1NPSR1 | |
| SCHEMBL21856319 | 0.84 | ALDH1A1 (0.42) | KMT2ALMNAPOLBKDM4EALDH1A1 | |
| SCHEMBL21856348 | 0.79 | PABPC1 (0.40) | KMT2ALMNAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL21856323 | 0.78 | IDH2 (0.45) | KMT2A | |
| SCHEMBL21856357 | 0.77 | RHOC (0.40) | KMT2A | |
| SCHEMBL21958962 | 0.77 | TEAD1 (0.57) | DDB1CRBNKMT2AEGFR | |
| SCHEMBL21958174 | 0.77 | TEAD1 (0.57) | DDB1CRBNKMT2AEGFR | |
| SCHEMBL21856331 | 0.73 | TAS2R14 (0.39) | KMT2AMAPT | |
| SCHEMBL21856326 | 0.73 | RHOC (0.42) | FFAR4 | |
| SCHEMBL21856354 | 0.73 | EGFR (0.39) | CYP3A4CYP2C9EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081572-A1 | TRANSCRIPTIONAL ENHANCED ASSOCIATE DOMAIN (TEAD) TRANSCRIPTION FACTOR INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-04-23 | — | — | WO | disclosed |