Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHOC | P08134 | 3/20 | 0.42 |
| ▸ | RHOA | P61586 | 3/20 | 0.42 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 5/20 | 0.37 |
| ▸ | SPR | P35270 | 1/20 | 0.36 |
| ▸ | DCUN1D1 | Q96GG9 | 5/20 | 0.35 |
| ▸ | UBE2M | P61081 | 4/20 | 0.35 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | TEC | P42680 | 1/20 | 0.34 |
| ▸ | TXK | P42681 | 1/20 | 0.34 |
| ▸ | BMX | P51813 | 1/20 | 0.34 |
| ▸ | ITK | Q08881 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21856357 | 0.92 | RHOC (0.40) | RHOCRHOADCUN1D1UBE2MCSF1R | |
| SCHEMBL21856348 | 0.83 | PABPC1 (0.40) | RHOADCUN1D1UBE2MHDAC3HDAC1 | |
| SCHEMBL21856323 | 0.82 | IDH2 (0.45) | DCUN1D1UBE2M | |
| SCHEMBL21856354 | 0.81 | EGFR (0.39) | RHOCRHOABTK | |
| SCHEMBL21856314 | 0.81 | DDR1 (0.39) | CSF1R | |
| SCHEMBL21856319 | 0.80 | ALDH1A1 (0.42) | DCUN1D1UBE2M | |
| SCHEMBL21856365 | 0.78 | BRAF (0.36) | RHOCRHOACSF1R | |
| SCHEMBL21958755 | 0.76 | TEAD1 (0.55) | RHOCRHOABTKSPRDCUN1D1 | |
| SCHEMBL21958158 | 0.76 | TEAD1 (0.55) | RHOCRHOABTKSPRDCUN1D1 | |
| SCHEMBL21856309 | 0.73 | SPR (0.43) | SPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081572-A1 | TRANSCRIPTIONAL ENHANCED ASSOCIATE DOMAIN (TEAD) TRANSCRIPTION FACTOR INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-04-23 | — | — | WO | disclosed |