Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | GBA1 | P04062 | 1/20 | 0.45 |
| ▸ | DNM1L | O00429 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24766048 | 0.84 | KMT2A (0.50) | SMN1; SMN2CRHBPCRHR2KDM4EGAA | |
| SCHEMBL20548133 | 0.83 | CRHBP (0.46) | SMN1; SMN2CRHBPCRHR2DNM1LKDM4E | |
| SCHEMBL25186884 | 0.75 | HRH3 (0.51) | HRH4 | |
| SCHEMBL2179648 | 0.75 | GBA1 (0.43) | SMN1; SMN2CRHBPCRHR2GBA1CYP1A2 | |
| SCHEMBL12250749 | 0.74 | CRHBP (0.59) | SMN1; SMN2CRHBPCRHR2GBA1KDM4E | |
| SCHEMBL21875283 | 0.73 | DNM1L (0.71) | DNM1L | |
| SCHEMBL12161257 | 0.73 | NOS2 (0.43) | ALDH1A1 | |
| SCHEMBL18003560 | 0.73 | CASP1 (0.42) | SMN1; SMN2CRHBPCRHR2GBA1CYP1A2 | |
| SCHEMBL23299953 | 0.72 | KMT2A (0.56) | SMN1; SMN2CRHBPCRHR2KDM4EGAA | |
| SCHEMBL24324093 | 0.72 | PDE10A (0.46) | SMN1; SMN2CRHBPCRHR2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11168080-B2 | Dynamin-1-like protein inhibitors | MITOBRIDGE, INC. (US) | 2021-11-09 | — | — | US | disclosed |
| US-11168080-B2 | Dynamin-1-like protein inhibitors | MITOBRIDGE, INC. (US) | 2021-11-09 | — | — | US | disclosed |
| US-20200131172-A1 | DYNAMIN-1-LIKE PROTEIN INHIBITORS | Astellas Engineered Small Molecules US, Incorporated | 2020-04-30 | — | — | US | disclosed |
| US-20200131172-A1 | DYNAMIN-1-LIKE PROTEIN INHIBITORS | Astellas Engineered Small Molecules US, Incorporated | 2020-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11168080-B2 | Dynamin-1-like protein inhibitors | DNM1L, DNM1, DNM2 | SMN1; SMN2 2970/4885CRHBP 845/4885CRHR2 3584/4885 |
| US-20200131172-A1 | DYNAMIN-1-LIKE PROTEIN INHIBITORS | DNM1L, DNM1, DNM2 | SMN1; SMN2 2970/4885CRHBP 845/4885CRHR2 3584/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.