Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.51 |
| ▸ | ABAT | P80404 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21885659 | 0.85 | GPR35 (0.56) | GPR35MAPK1TP53HPGDTSHR | |
| SCHEMBL29379293 | 0.79 | TSHR (0.56) | MAPK1TSHRSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL9998849 | 0.79 | TSHR (0.56) | MAPK1TSHRSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL8031393 | 0.78 | ALDH1A1 (0.46) | MAPK1HPGDALDH1A1MAPTKDM4E | |
| SCHEMBL8041974 | 0.78 | MAPT (0.58) | GPR35TSHRALDH1A1L3MBTL1ALOX15 | |
| SCHEMBL18607548 | 0.78 | VCAM1 (0.51) | MAPK1TSHRMAPT | |
| SCHEMBL8031398 | 0.77 | DTYMK (0.45) | TSHRALDH1A1ALOX15MAPTKDM4E | |
| SCHEMBL229093 | 0.75 | MAPK1 (0.62) | GPR35MAPK1TP53HPGDTSHR | |
| SCHEMBL18956859 | 0.74 | MAPT (0.51) | HPGDTSHRSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL30072759 | 0.74 | MAPT (0.51) | HPGDTSHRSMN1; SMN2ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3601235-B1 | BICYCLIC HETEROARYL DERIVATIVES, PREPARATION AND THERAPEUTIC USES THEREOF | XWPHARMA LTD (KY) | 2026-03-04 | — | — | EP | disclosed |
| US-12398097-B2 | WDR5-MYC inhibitors | VANDERBILT UNIVERSITY (US) | 2025-08-26 | — | — | US | disclosed |
| US-11905247-B2 | Compounds as neurokinin-1 receptor antagonists and uses thereof | XWPharma Ltd. (KY) | 2024-02-20 | — | — | US | disclosed |
| CN-111770914-B | Compounds as neurokinin-1 receptor antagonists and uses thereof | 凯瑞康宁生物工程（武汉）有限公司 | 2023-06-20 | — | — | CN | disclosed |
| US-11639337-B2 | Bicyclic heteroaryl derivatives and preparation and uses thereof | XWPharma Ltd. (KY) | 2023-05-02 | — | — | US | disclosed |
| US-20220298127-A1 | BICYCLIC HETEROARYL DERIVATIVES AND PREPARATION AND USES THEREOF | XWPharma Ltd. (KY) | 2022-09-22 | — | — | US | disclosed |
| US-20220289673-A1 | WDR5-MYC INHIBITORS | VANDERBILT UNIVERSITY | 2022-09-15 | — | — | US | disclosed |
| CN-115025086-A | Bicyclic heteroaryl derivatives, their preparation and use | 凯瑞康宁生物工程（武汉）有限公司 | 2022-09-09 | — | — | CN | disclosed |
| US-11401249-B2 | Bicyclic heteroaryl derivatives and preparation and uses thereof | XWPharma Ltd. (KY) | 2022-08-02 | — | — | US | disclosed |
| CN-110709386-B | Bicyclic heteroaryl derivatives, their preparation and use | 凯瑞康宁生物工程（武汉）有限公司 | 2022-06-07 | — | — | CN | disclosed |
| US-20220002246-A1 | COMPOUNDS AS NEUROKININ-1 RECEPTOR ANTAGONISTS AND USES THEREOF | XWPharma Ltd. (KY) | 2022-01-06 | — | — | US | disclosed |
| US-11149006-B2 | Compounds as neurokinin-1 receptor antagonists and uses thereof | XWPharma Ltd. (KY) | 2021-10-19 | — | — | US | disclosed |
| US-20210094925-A1 | BICYCLIC HETEROARYL DERIVATIVES AND PREPARATION AND USES THEREOF | XWPharma Ltd. (KY) | 2021-04-01 | — | — | US | disclosed |
| WO-2021021951-A1 | WDR5-MYC INHIBITORS | VANDERBILT UNIVERSITY (US) | 2021-02-04 | — | — | WO | disclosed |
| US-10882832-B2 | Bicyclic heteroaryl derivatives and preparation and uses thereof | XW LABORATORIES INC. (KY) | 2021-01-05 | — | — | US | disclosed |
| CN-111770914-A | Compounds as neurokinin-1 receptor antagonists and uses thereof | 凯瑞康宁生物工程（武汉）有限公司 | 2020-10-13 | — | — | CN | disclosed |
| US-20200239416-A1 | COMPOUNDS AS NEUROKININ-1 RECEPTOR ANTAGONISTS AND USES THEREOF | XWPharma Ltd. (KY) | 2020-07-30 | — | — | US | disclosed |
| US-20200181102-A1 | BICYCLIC HETEROARYL DERIVATIVES AND PREPARATION AND USES THEREOF | XWPharma Ltd. (KY) | 2020-06-11 | — | — | US | disclosed |
| US-10640476-B2 | Bicyclic heteroaryl derivatives and preparation and uses thereof | XW LABORATORIES INC. (KY) | 2020-05-05 | — | — | US | disclosed |
| CN-110709386-A | Bicyclic heteroaryl derivatives, their preparation and use | 凯瑞康宁生物工程（武汉）有限公司 | 2020-01-17 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11905247-B2 | Compounds as neurokinin-1 receptor antagonists and uses thereof | TACR1, KISS1R, TACR2 | GPR35 164/4885MAPK1 674/4885TP53 3315/4885 |
| US-20220289673-A1 | WDR5-MYC INHIBITORS | MYC, WDR5, MYCBP | GPR35 2548/4885MAPK1 1530/4885TP53 142/4885 |
| US-20220298127-A1 | BICYCLIC HETEROARYL DERIVATIVES AND PREPARATION AND USES THEREOF | GRIN2A, GRIN2C, GRIN3A | GPR35 133/4885MAPK1 2264/4885TP53 3688/4885 |
| US-20220002246-A1 | COMPOUNDS AS NEUROKININ-1 RECEPTOR ANTAGONISTS AND USES THEREOF | TACR1, KISS1R, TACR2 | GPR35 164/4885MAPK1 674/4885TP53 3315/4885 |
| US-10882832-B2 | Bicyclic heteroaryl derivatives and preparation and uses thereof | GRIN2A, GRIN2C, GRIN3A | GPR35 133/4885MAPK1 2264/4885TP53 3688/4885 |
| US-11401249-B2 | Bicyclic heteroaryl derivatives and preparation and uses thereof | GRIN2A, GRIN2C, GRIN3A | GPR35 133/4885MAPK1 2264/4885TP53 3688/4885 |
| US-20200181102-A1 | BICYCLIC HETEROARYL DERIVATIVES AND PREPARATION AND USES THEREOF | GRIN2A, GRIN2C, GRIN3A | GPR35 133/4885MAPK1 2264/4885TP53 3688/4885 |
| US-10640476-B2 | Bicyclic heteroaryl derivatives and preparation and uses thereof | GRIN2A, GRIN2C, GRIN3A | GPR35 133/4885MAPK1 2264/4885TP53 3688/4885 |
| US-11639337-B2 | Bicyclic heteroaryl derivatives and preparation and uses thereof | GRIN2A, GRIN2C, GRIN3A | GPR35 133/4885MAPK1 2264/4885TP53 3688/4885 |
| US-20200239416-A1 | COMPOUNDS AS NEUROKININ-1 RECEPTOR ANTAGONISTS AND USES THEREOF | TACR1, KISS1R, TACR2 | GPR35 164/4885MAPK1 674/4885TP53 3315/4885 |
| US-12398097-B2 | WDR5-MYC inhibitors | MYC, WDR5, MYCBP | GPR35 2548/4885MAPK1 1530/4885TP53 142/4885 |
| US-11149006-B2 | Compounds as neurokinin-1 receptor antagonists and uses thereof | TACR1, KISS1R, TACR2 | GPR35 164/4885MAPK1 674/4885TP53 3315/4885 |
| US-20210094925-A1 | BICYCLIC HETEROARYL DERIVATIVES AND PREPARATION AND USES THEREOF | GRIN2A, GRIN2C, GRIN3A | GPR35 133/4885MAPK1 2264/4885TP53 3688/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.