Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 10/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HSD17B3 | P37058 | 4/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.39 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18407434 | 0.79 | NOTUM (0.53) | NOTUMHSD17B3CES1CYP2D6CYP2C9 | |
| SCHEMBL20125004 | 0.74 | LMNA (0.38) | NOTUMLMNACES1KDM4EALDH1A1 | |
| SCHEMBL21065872 | 0.73 | NOTUM (0.54) | NOTUMLMNAHSD17B3KCNN4KCNA3 | |
| SCHEMBL30003296 | 0.73 | NOTUM (1.00) | NOTUMLMNAHSD17B3CES1CYP2D6 | |
| SCHEMBL1048074 | 0.73 | NOTUM (1.00) | NOTUMLMNAHSD17B3CES1CYP2D6 | |
| SCHEMBL4432600 | 0.72 | CES1 (0.35) | NOTUMLMNACES1KDM4EALDH1A1 | |
| SCHEMBL29738286 | 0.72 | CES1 (0.35) | NOTUMLMNACES1KDM4EALDH1A1 | |
| SCHEMBL25963738 | 0.71 | NOTUM (0.60) | NOTUMHSD17B3KDM4E | |
| Bromide SCHEMBL28230837 | 0.71 | CA12 (0.40) | LMNACYP2D6CYP2C9KDM4EALDH1A1 | |
| Iodide SCHEMBL27878012 | 0.71 | CES1 (0.34) | NOTUMLMNACES1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9796678-B2 | Method for manufacturing optically active compound | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2017-10-24 | — | — | US | disclosed |
| US-9796678-B2 | Method for manufacturing optically active compound | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2017-10-24 | — | — | US | disclosed |
| EP-2197445-B1 | TSH RECEPTOR ANTAGONIZING TETRAHYDROQUINOLINE COMPOUNDS | MERCK SHARP & DOHME (NL) | 2017-04-19 | — | — | EP | disclosed |
| US-20170022162-A1 | METHOD FOR MANUFACTURING OPTICALLY ACTIVE COMPOUND | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2017-01-26 | — | — | US | disclosed |
| US-9174940-B2 | TSH receptor antagonizing tetrahydroquinoline compounds | MERCK SHARP & DOHME B.V. (NL) | 2015-11-03 | — | — | US | disclosed |
| US-20110172267-A1 | TSH receptor antagonizing tetrahydroquinoline compounds | N.V. ORGANON | 2011-07-14 | — | — | US | disclosed |
| US-7858794-B2 | Tetrahydroquinoline derivatives | N.V. ORGANON (NL) | 2010-12-28 | — | — | US | disclosed |
| US-7858794-B2 | Tetrahydroquinoline derivatives | N.V. ORGANON (NL) | 2010-12-28 | — | — | US | disclosed |
| US-7858794-B2 | Tetrahydroquinoline derivatives | N.V. ORGANON (NL) | 2010-12-28 | — | — | US | disclosed |
| US-7674909-B2 | Biphenyl-4-carboxylic acid {1-acetyl-4-[4-(2-dimethylammo-ethoxy-phenyl]-2,2,4-trimethyl-1,2,3,4-tetrahydro-quinolin-6-yl}-amide; fertility regulation; follicle stimulating hormone (FSH) | N.V. ORGANON (NL) | 2010-03-09 | — | — | US | disclosed |
| EP-1578726-B1 | TETRAHYDROQUINOLINE DERIVATIVES | ORGANON NV (NL) | 2009-02-25 | — | — | EP | disclosed |
| EP-1578726-B1 | TETRAHYDROQUINOLINE DERIVATIVES | ORGANON NV (NL) | 2009-02-25 | — | — | EP | disclosed |
| EP-1578727-B1 | TETRAHYDROQUINOLINE DERIVATIVES AND THEIR USE AS FSH RECEPTOR MODULATORS | ORGANON NV (NL) | 2008-04-16 | — | — | EP | disclosed |
| US-20060167047-A1 | Tetrahydorquinoline derivatives and their use as fsh receptor modulators | MERCK SHARP & DOHME B.V. (NL) | 2006-07-27 | — | — | US | disclosed |
| US-20060142334-A1 | Tetrahydroquinoline derivatives | MERCK SHARP & DOHME B.V. (NL) | 2006-06-29 | — | — | US | disclosed |
| EP-1578727-A2 | TETRAHYDROQUINOLINE DERIVATIVES AND THEIR USE AS FSH RECEPTOR MODULATORS | Akzo Nobel N.V. (NL) | 2005-09-28 | — | — | EP | disclosed |
| WO-2004056779-A2 | TETRAHYDROQUINOLINE DERIVATIVES AND THEIR USE AS FSH RECEPTOR MODULATORS | AKZO NOBEL N.V. (NL) | 2004-07-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060142334-A1 | Tetrahydroquinoline derivatives | GNRHR, KCNH3, HCAR3 | NOTUM 4283/4885LMNA 2156/4885HSD17B3 226/4885 |
| US-20110172267-A1 | TSH receptor antagonizing tetrahydroquinoline compounds | TSHR, MC1R, TRHR | NOTUM 4079/4885LMNA 1653/4885HSD17B3 2350/4885 |
| US-20170022162-A1 | METHOD FOR MANUFACTURING OPTICALLY ACTIVE COMPOUND | C9, C5, PRMT7 | NOTUM 1196/4885LMNA 3744/4885HSD17B3 622/4885 |
| US-20060167047-A1 | Tetrahydorquinoline derivatives and their use as fsh receptor modulators | FSHR, GNRHR, LHCGR | NOTUM 3996/4885LMNA 4010/4885HSD17B3 191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.