Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 12/20 | 0.46 |
| ▸ | PPARG | P37231 | 9/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | PTGES | O14684 | 7/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28392771 | 0.83 | ALDH1A1 (0.45) | ALOX5PPARGALDH1A1PTGESCYP2C9 | |
| SCHEMBL21964369 | 0.79 | ALOX5 (0.47) | ALOX5PPARGALDH1A1PTGESCYP2C9 | |
| SCHEMBL15641295 | 0.78 | AKR1B1 (0.51) | ALOX5PPARGALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL448107 | 0.78 | AKR1B1 (0.51) | ALOX5PPARGALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL8120419 | 0.78 | AKR1B1 (0.51) | ALOX5PPARGALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL27890998 | 0.76 | AKR1B1 (0.50) | ALOX5PPARGALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL5511628 | 0.75 | ALDH1A1 (0.46) | ALOX5PPARGALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL6661896 | 0.74 | ALOX5 (0.46) | ALOX5PPARGPTGES | |
| SCHEMBL20171040 | 0.73 | SLC6A4 (0.46) | ALDH1A1CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL21961154 | 0.73 | CYP2D6 (0.46) | ALDH1A1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220144784-A1 | NOVEL AZOLE DERIVATIVES AS APELIN RECEPTOR AGONIST | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2022-05-12 | — | — | US | disclosed |
| US-11155525-B2 | Azole derivatives as apelin receptor agonist | Sanford Burnham Prebys Medical Discovery Institute (US) | 2021-10-26 | — | — | US | disclosed |
| US-20200347022-A1 | NOVEL AZOLE DERIVATIVES AS APELIN RECEPTOR AGONIST | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2020-11-05 | — | — | US | disclosed |
| US-10626096-B2 | Azole derivatives as apelin receptor agonist | Sanford Burnham Prebys Medical Discovery Institute (US) | 2020-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11155525-B2 | Azole derivatives as apelin receptor agonist | APLNR, AGTR1, AGTR2 | ALOX5 1449/4885PPARG 1357/4885ALDH1A1 2642/4885 |
| US-20200347022-A1 | NOVEL AZOLE DERIVATIVES AS APELIN RECEPTOR AGONIST | APLNR, AGTR1, AGTR2 | ALOX5 1585/4885PPARG 1456/4885ALDH1A1 2968/4885 |
| US-20220144784-A1 | NOVEL AZOLE DERIVATIVES AS APELIN RECEPTOR AGONIST | APLNR, AGTR1, AGTR2 | ALOX5 1634/4885PPARG 1626/4885ALDH1A1 2845/4885 |
| US-10626096-B2 | Azole derivatives as apelin receptor agonist | APLNR, AGTR1, AGTR2 | ALOX5 1476/4885PPARG 1346/4885ALDH1A1 2622/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.