Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.42 |
| ▸ | KDM1A | O60341 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | SMO | Q99835 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LSS | P48449 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL221237 | 0.80 | ACHE (0.42) | KDM1ATSHRALDH1A1ACHE | |
| SCHEMBL219902 | 0.78 | KDM1A (0.42) | KDM1AMAOBTSHRSMOLSS | |
| SCHEMBL222333 | 0.78 | MAOB (0.52) | HTR1AKDM1AMAOBALDH1A1ACHE | |
| SCHEMBL2517968 | 0.73 | HTR1A (0.66) | HTR1A | |
| SCHEMBL19739574 | 0.72 | HPGD (0.56) | HTR1AALDH1A1ACHE | |
| SCHEMBL3871671 | 0.72 | ITGB3 (0.44) | KDM1AMAOBLSS | |
| SCHEMBL4457921 | 0.71 | HPGD (0.60) | HTR1AALDH1A1L3MBTL1ACHESMN1; SMN2 | |
| SCHEMBL16528120 | 0.70 | MAPK1 (0.46) | ALDH1A1HSD17B10ACHESMN1; SMN2 | |
| SCHEMBL3439989 | 0.70 | L3MBTL1 (0.47) | KDM1AMAOBALDH1A1L3MBTL1ACHE | |
| SCHEMBL221271 | 0.68 | F10 (0.68) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088925-B2 | low molecular weight factor Xa specific blood clotting inhibitors; less side effects; 5-Chloro-thiophene-2-carboxylic acid [2-(1-isopropyl-piperidin-4-ylsulfamoyl)-ethyl]-amide; thromboembolic diseases or restenosis; antithrombotic agents | SANOFI-AVENTIS (FR) | 2012-01-03 | — | — | US | disclosed |
| EP-1888567-A1 | HETEROARYL-CARBOXYLIC ACID (SULFAMOYL ALKYL) AMIDE - DERIVATIVES AS FACTOR XA INHIBITORS | Sanofi-Aventis (FR) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006122661-A1 | HETEROARYL-CARBOXYLIC ACID (SULFAMOYL ALKYL) AMIDE - DERIVATIVES AS FACTOR XA INHIBITORS | SANOFI-AVENTIS (DE) | 2006-11-23 | — | — | WO | disclosed |