Water

Water

SCHEMBL2197935

O.O.O.O.O.O.O=C(O)c1ccccc1C(=O)OO.[MgH2]

nearest known ligand 0.61

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 known ✓ P03372 1/20 0.47
ITGB3 known ✓ P05106 1/20 0.47
ITGA2B known ✓ P08514 1/20 0.47
PTGS1 known ✓ P23219 1/20 0.47
PTGS2 known ✓ P35354 1/20 0.47
PDE3A known ✓ Q14432 1/20 0.46
HDAC8 known ✓ Q9BY41 1/20 0.45
ALDH1A1 P00352 10/20 0.61
ALOX15 P16050 1/20 0.61
AKR1C3 P42330 1/20 0.48
KDM4E B2RXH2 7/20 0.47
HPGD P15428 7/20 0.47
HSD17B10 Q99714 6/20 0.47
HMGB1 P09429 2/20 0.47
NAPRT Q6XQN6 2/20 0.47
TSHR P16473 1/20 0.47
GGT1 P19440 1/20 0.47
BLM P54132 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
CA12 O43570 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Water SCHEMBL27797324 1.00 ALDH1A1 (0.61) ALDH1A1ALOX15AKR1C3KDM4EHPGD
Water SCHEMBL7473392 1.00 ALDH1A1 (0.61) ALDH1A1ALOX15AKR1C3KDM4EHPGD
Water SCHEMBL1115165 0.98 ALDH1A1 (0.64) ALDH1A1ALOX15AKR1C3KDM4EHPGD
SCHEMBL154505 0.98 ALDH1A1 (0.64) ALDH1A1ALOX15AKR1C3KDM4EHPGD
Water SCHEMBL4303934 0.98 ALDH1A1 (0.64) ALDH1A1ALOX15AKR1C3KDM4EHPGD
Water SCHEMBL10792720 0.98 ALDH1A1 (0.64) ALDH1A1ALOX15AKR1C3KDM4EHPGD
Water SCHEMBL8643839 0.96 ALDH1A1 (0.61) ALDH1A1ALOX15AKR1C3KDM4EHPGD
Water SCHEMBL27370626 0.96 ALDH1A1 (0.61) ALDH1A1ALOX15AKR1C3KDM4EHPGD
Water SCHEMBL951511 0.96 ALDH1A1 (0.61) ALDH1A1ALOX15AKR1C3KDM4EHPGD
Water SCHEMBL9614449 0.96 ALDH1A1 (0.61) ALDH1A1ALOX15AKR1C3KDM4EHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 124 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101631777-A Triol form of rosuvastatin TEVA PHARMA 2010-01-20 CN claimed
US-7037894-B2 Stabilized proteins AVATAR MEDICAL, LLC (US) 2006-05-02 US claimed
CN-1162529-C Laundry detergent compositions comprising cationic surfactants and modified polyamine soil dispersents ���޸���-�ʲ�����˾ 2004-08-18 CN claimed
CN-110423653-A A kind of tableware dipping powder SHENZHEN YAOXING IND CO LTD 2019-11-08 CN disclosed
US-20190093000-A1 SELF-SUSPENDING MATERILAL FOR DIVERSION APPLICATIONS HALLIBURTON ENERGY SERVICES, INC. (US) 2019-03-28 US disclosed
CN-109415404-A 6,7- α-process for epoxidation and intermediate for steroids 4,6- diene NZP英国有限公司 2019-03-01 CN disclosed
CN-105829305-B NRF2 regulator 葛兰素史密斯克莱知识产权发展有限公司 2018-11-30 CN disclosed
WO-2017213657-A1 SELF-SUSPENDING MATERILAL FOR DIVERSION APPLICATIONS HALLIBURTON ENERGY SERVICES, INC. (US) 2017-12-14 WO disclosed
CN-107207559-A 6-alkyl-7-hydroxy-4-en-3-ones as intermediates for the preparation of steroid FXR modulators NZP英国有限公司 2017-09-26 CN disclosed
CN-107207558-A 6 alpha-alkyl-6, 7-diketosteroids as intermediates for the preparation of steroid FXR modulators NZP英国有限公司 2017-09-26 CN disclosed
CN-107108687-A It is used as the ketosteroid of 5 β, 6 alkyl, 7 hydroxyl 3 for the intermediate for preparing steroids FXR conditioning agents NZP英国有限公司 2017-08-29 CN disclosed
EP-0625987-A1 AMINOACETYLMERCAPTOACETYLAMIDE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE MERRELL PHARMACEUTICALS INC. (US) 1994-11-30 EP disclosed
WO-1994006777-A1 HETEROCYCLIC COMPOUNDS WIHT PARASITICAL ACTIVITY ZENECA LIMITED (GB) 1994-03-31 WO disclosed
WO-1994006782-A1 BENZOXAZOLE AND BEZOTHIAZOLE DERIVATIVES ZENECA LIMITED (GB) 1994-03-31 WO disclosed
US-5250536-A Trifluorobutenylmercaptopyrimidine derivatives, nematocides IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1993-10-05 US disclosed
WO-1993016103-A1 AMINOACETYLMERCAPTOACETYLAMIDE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE MERRELL DOW PHARMACEUTICALS INC. (US) 1993-08-19 WO disclosed
EP-0533868-A1 NEMATOCIDE PYRIMIDINE DERIVATIVES ZENECA LIMITED (GB) 1993-03-31 EP disclosed
CN-1069763-A Detergent composition PROCTER & GAMBLE (US) 1993-03-10 CN disclosed
WO-1992017458-A1 NEMATOCIDE PYRIMIDINE DERIVATIVES IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1992-10-15 WO disclosed
EP-0506271-A1 Nematocide pyrimidine derivatives ZENECA LIMITED (GB) 1992-09-30 EP disclosed