Water

Water

SCHEMBL951511

O.O.O.O.O.O.O=C(O)c1ccccc1C(=O)OO.O=C(O)c1ccccc1C(=O)OO.[Mg]

nearest known ligand 0.61

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 known ✓ P03372 1/20 0.47
ITGB3 known ✓ P05106 1/20 0.47
ITGA2B known ✓ P08514 1/20 0.47
PTGS1 known ✓ P23219 1/20 0.47
PTGS2 known ✓ P35354 1/20 0.47
PDE3A known ✓ Q14432 1/20 0.46
HDAC8 known ✓ Q9BY41 1/20 0.45
ALDH1A1 P00352 10/20 0.61
ALOX15 P16050 1/20 0.61
AKR1C3 P42330 1/20 0.48
KDM4E B2RXH2 7/20 0.47
HPGD P15428 7/20 0.47
HSD17B10 Q99714 6/20 0.47
HMGB1 P09429 2/20 0.47
NAPRT Q6XQN6 2/20 0.47
TSHR P16473 1/20 0.47
GGT1 P19440 1/20 0.47
BLM P54132 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
CA12 O43570 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Water SCHEMBL8643839 1.00 ALDH1A1 (0.61) ALDH1A1ALOX15AKR1C3KDM4EHPGD
Water SCHEMBL10792720 0.98 ALDH1A1 (0.64) ALDH1A1ALOX15AKR1C3KDM4EHPGD
Water SCHEMBL1115165 0.98 ALDH1A1 (0.64) ALDH1A1ALOX15AKR1C3KDM4EHPGD
Magnesium SCHEMBL960154 0.98 ALDH1A1 (0.64) ALDH1A1ALOX15AKR1C3KDM4EHPGD
Water SCHEMBL4303934 0.98 ALDH1A1 (0.64) ALDH1A1ALOX15AKR1C3KDM4EHPGD
Water SCHEMBL27797324 0.96 ALDH1A1 (0.61) ALDH1A1ALOX15AKR1C3KDM4EHPGD
Water SCHEMBL27370626 0.96 ALDH1A1 (0.61) ALDH1A1ALOX15AKR1C3KDM4EHPGD
Water SCHEMBL2197935 0.96 ALDH1A1 (0.61) ALDH1A1ALOX15AKR1C3KDM4EHPGD
Water SCHEMBL7473392 0.96 ALDH1A1 (0.61) ALDH1A1ALOX15AKR1C3KDM4EHPGD
Water SCHEMBL9614449 0.96 ALDH1A1 (0.61) ALDH1A1ALOX15AKR1C3KDM4EHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 115 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100301288-A1 PREPARATION OF NUCLEAR FUEL COMPOSITION AND RECYCLING LOS ALAMOS NATIONAL SECURITY, LLC (US) 2010-12-02 US claimed
US-20090270499-A1 Process for Synthesizing Atazanavir OXYRANE (UK) LIMITED (UK) 2009-10-29 US claimed
WO-2009130534-A1 PROCESS FOR SYNTHESIZING ATAZANAVIR OXYRANE (PTY) LTD. (ZA) 2009-10-29 WO claimed
US-12534442-B2 Benzisoxazole derivative Sumitomo Pharma Co., Ltd. (JP) 2026-01-27 US disclosed
US-20260015313-A1 AMINO ACID ACTIVE ESTER AND SALT THEREOF PEPTIDREAM INC (JP) 2026-01-15 US disclosed
WO-2025242860-A2 PHYTOSTEROL DERIVATIVES, AND COMPOSITIONS COMPRISING THE SAME, FOR USE AS MEDICAMENTS Institut National de la Santé et de la Recherche Médicale (FR) 2025-11-27 WO disclosed
EP-4646421-A1 FLUORO-OXYSTEROLS POSITRON EMISSION TOMOGRAPHY (PET) RADIOTRACERS Institut National de la Santé et de la Recherche Médicale (FR) 2025-11-12 EP disclosed
EP-4534524-A1 AMINO ACID ACTIVE ESTER AND SALT THEREOF PeptiDream Inc. (JP) 2025-04-09 EP disclosed
US-20250059200-A1 PROCESS FOR C-H INSERTION BY GEM-HYDROGENATION OF AN INTERNAL ALKYNE STUDIENGESELLSCHAFT KOHLE GGMBH (DE) 2025-02-20 US disclosed
WO-2024146880-A1 FLUORO-OXYSTEROLS POSITRON EMISSION TOMOGRAPHY (PET) RADIOTRACERS Institut National de la Santé et de la Recherche Médicale (FR) 2024-07-11 WO disclosed
US-11858953-B2 Compositions and methods for synthesis of phosphorylated molecules THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-01-02 US disclosed
US-5792879-A OXIDIZING LEUCO COMPOUND IN PRESENCE OF DILUENT AND HEAVY METAL COMPLEX OXYGEN TRANSFER CATALYST WITH HYDROGEN PEROXIDE, ORGANIC HYDROPEROXIDE OR PERCARBOXYLIC ACID BASF AKTIENGESELLSCHAFT (DE) 1998-08-11 US disclosed
US-5712416-A Preparation of benzoquinones by oxidation of phenols BASF AKTIENGESELLSCHAFT (DE) 1998-01-27 US disclosed
EP-0659727-B1 Process for the preparation of benzoquinones by oxidation of phenoles BASF AG (DE) 1997-08-27 EP disclosed
US-5659053-A REACTING A LEUCO COMPOUND WITH HYDROGEN PEROXIDE USING AN OXYGEN TRANSFER CATALYST IN THE PRESENCE OF A DILUENT AND THE ABSENCE OF CHLORANIL BASF AKTIENGESELLSCHAFT (DE) 1997-08-19 US disclosed
EP-0568806-B1 Method for producing diarylmethane or triarylmethane dyestuffs by oxidation BASF AG (DE) 1997-06-11 EP disclosed
EP-0659727-A1 Process for the preparation of benzoquinones by oxidation of phenoles BASF AKTIENGESELLSCHAFT (DE) 1995-06-28 EP disclosed
US-5428140-A Oxidation of disazo dye with hydrogen peroxide forming fiber reactive dyes BASF AKTIENGESELLSCHAFT (DE) 1995-06-27 US disclosed
EP-0630947-A1 Phenylazo- or Naphthylazobenzoles having thioether groups BASF Aktiengesellschaft (DE) 1994-12-28 EP disclosed
EP-0568806-A1 Method for producing diarylmethane or triarylmethane dyestuffs by oxidation BASF Aktiengesellschaft (DE) 1993-11-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11858953-B2 Compositions and methods for synthesis of phosphorylated molecules PIK3CA, CHAMP1, TYMP ESR1 2641/4885ITGB3 2206/4885ITGA2B 3519/4885
US-20250059200-A1 PROCESS FOR C-H INSERTION BY GEM-HYDROGENATION OF AN INTERNAL ALKYNE GGH, GEMIN4, GMNN ESR1 2117/4885ITGB3 2199/4885ITGA2B 3050/4885
US-20260015313-A1 AMINO ACID ACTIVE ESTER AND SALT THEREOF NSUN3, BCAT1, SLC43A1 ESR1 2780/4885ITGB3 2864/4885ITGA2B 3805/4885
US-12534442-B2 Benzisoxazole derivative GABRA6, SLC6A1, GABRA1 ESR1 4274/4885ITGB3 1510/4885ITGA2B 3495/4885
US-20090270499-A1 Process for Synthesizing Atazanavir SAMHD1, TYMS, COASY ESR1 2933/4885ITGB3 4591/4885ITGA2B 4501/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.