Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.85 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | CXCR4 | P61073 | 7/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.56 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.56 |
| ▸ | CCR2 | P41597 | 1/20 | 0.56 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL7452259 | 0.93 | SIGMAR1 (0.79) | SIGMAR1ALDH1A1KMT2AMEN1CYP2C9 | |
| Urea SCHEMBL6942597 | 0.93 | SIGMAR1 (0.79) | SIGMAR1ALDH1A1KMT2AMEN1CYP2C9 | |
| SCHEMBL276363 | 0.92 | SIGMAR1 (1.00) | SIGMAR1ALDH1A1KMT2AMEN1CYP2C9 | |
| SCHEMBL83548 | 0.92 | SIGMAR1 (1.00) | SIGMAR1ALDH1A1KMT2AMEN1CYP2C9 | |
| SCHEMBL6138636 | 0.92 | SIGMAR1 (1.00) | SIGMAR1ALDH1A1KMT2AMEN1CYP2C9 | |
| SCHEMBL152631 | 0.92 | SIGMAR1 (1.00) | SIGMAR1ALDH1A1KMT2AMEN1CYP2C9 | |
| Benzene SCHEMBL27761330 | 0.92 | SIGMAR1 (1.00) | SIGMAR1ALDH1A1KMT2AMEN1CYP2C9 | |
| SCHEMBL7573306 | 0.90 | SIGMAR1 (0.96) | SIGMAR1ALDH1A1KMT2AMEN1CYP2C9 | |
| SCHEMBL8145866 | 0.90 | SIGMAR1 (0.96) | SIGMAR1ALDH1A1KMT2AMEN1CYP2C9 | |
| Hydrochloric Acid SCHEMBL2223234 | 0.90 | SIGMAR1 (0.96) | SIGMAR1ALDH1A1KMT2AMEN1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118085169-A | Hydrolyzed maleic anhydride copolymer scale inhibitor and preparation method thereof | 安徽海螺制剂工程技术有限公司 | 2024-05-28 | — | — | CN | claimed |
| CN-114540843-B | Electrochemical synthesis method of sulfenamide compound | 上海应用技术大学 | 2024-01-23 | — | — | CN | claimed |
| CN-114540843-A | Electrochemical synthesis method of sulfenamide compound | 上海应用技术大学 | 2022-05-27 | — | — | CN | claimed |
| CN-118255780-A | Compound for inhibiting and degrading c-MYC and medical application thereof | 西藏海思科制药有限公司 | 2024-06-28 | — | — | CN | disclosed |
| CN-118221669-A | Derivatives as DNA polymerase Theta inhibitors | 艾立康药业股份有限公司 | 2024-06-21 | — | — | CN | disclosed |
| CN-118085169-A | Hydrolyzed maleic anhydride copolymer scale inhibitor and preparation method thereof | 安徽海螺制剂工程技术有限公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-118005610-A | PARP-1 degrading agent and application thereof | 西藏海思科制药有限公司 | 2024-05-10 | — | — | CN | disclosed |
| CN-118019740-A | Heteroaryl derivative PARP inhibitors and uses thereof | 海思科医药集团股份有限公司 | 2024-05-10 | — | — | CN | disclosed |
| CN-117903225-A | Liver tissue targeted delivery compound, preparation method and application thereof | 思合基因(北京)生物科技有限公司 | 2024-04-19 | — | — | CN | disclosed |
| WO-2024066548-A1 | β-ELEMENE DERIVATIVE CONTAINING PHOTOAFFINITY GROUP DIAZIRINE, PREPARATION METHOD THEREFOR, AND USE THEREOF AS PHOTOAFFINITY MOLECULAR PROBE | 杭州师范大学 | 2024-04-04 | — | — | WO | disclosed |
| WO-2024067857-A1 | MACROCYCLIC DERIVATIVE AND USE THEREOF | 南京明德新药研发有限公司 | 2024-04-04 | — | — | WO | disclosed |
| CN-116410182-A | CCR4 small molecule antagonist and application thereof | 瑞石生物医药有限公司 | 2023-07-11 | — | — | CN | disclosed |
| CN-116323624-A | Quinazoline compound and application thereof | 上海医药集团股份有限公司 | 2023-06-23 | — | — | CN | disclosed |
| WO-2023051716-A1 | HETEROARYL DERIVATIVE PARP INHIBITOR AND USE THEREOF | 海思科医药集团股份有限公司 | 2023-04-06 | — | — | WO | disclosed |
| CN-114540843-A | Electrochemical synthesis method of sulfenamide compound | 上海应用技术大学 | 2022-05-27 | — | — | CN | disclosed |
| EP-3656782-B1 | PEPTIDE AMIDE COMPOUND AND PREPARATION METHOD AND MEDICAL USE THEREOF | SICHUAN HAISCO PHARMACEUTICAL CO LTD (CN) | 2021-12-22 | — | — | EP | disclosed |
| US-11014964-B2 | Peptide amide compound and preparation method and medical use thereof | SICHUAN HAISCO PHARMACEUTICAL CO., LTD. (CN) | 2021-05-25 | — | — | US | disclosed |
| US-20200172573-A1 | PEPTIDE AMIDE COMPOUND AND PREPARATION METHOD AND MEDICAL USE THEREOF | SICHUAN HAISCO PHARMACEUTICAL CO., LTD. (CN) | 2020-06-04 | — | — | US | disclosed |
| EP-3656782-A1 | PEPTIDE AMIDE COMPOUND AND PREPARATION METHOD AND MEDICAL USE THEREOF | Sichuan Haisco Pharmaceutical Co., Ltd. (CN) | 2020-05-27 | — | — | EP | disclosed |
| US-9422295-B2 | Deuterated ibrutinib | CONCERT PHARMACEUTICALS, INC. (US) | 2016-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200172573-A1 | PEPTIDE AMIDE COMPOUND AND PREPARATION METHOD AND MEDICAL USE THEREOF | VIP, NPPA, GRPR | SIGMAR1 919/4885ALDH1A1 3909/4885KMT2A 3523/4885 |
| US-11014964-B2 | Peptide amide compound and preparation method and medical use thereof | VIP, NPPA, GRPR | SIGMAR1 919/4885ALDH1A1 3909/4885KMT2A 3523/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.