Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | ACLY | P53396 | 1/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30582466 | 0.85 | MAOA (0.60) | KDM4EMAPTHCRTR1CASP1CASP7 | |
| SCHEMBL19052340 | 0.83 | MEN1 (0.50) | KDM4EMAPTCYP11B2PTGS2MAOA | |
| SCHEMBL3852371 | 0.81 | CYP11B2 (0.47) | KDM4EMAPTACLYCYP11B2PTGS2 | |
| SCHEMBL22005102 | 0.80 | ACLY (0.46) | KDM4EMAPTHCRTR1CASP1CASP7 | |
| SCHEMBL10067380 | 0.79 | CYP11B2 (0.68) | KDM4EMAPTCYP11B2ALDH1A1LMNA | |
| SCHEMBL28282812 | 0.79 | MAPT (0.46) | KDM4EMAPTHCRTR1CASP1CASP7 | |
| SCHEMBL7601837 | 0.79 | ALDH1A1 (0.68) | KDM4EMAPTHCRTR1CASP1CASP7 | |
| SCHEMBL3856953 | 0.77 | ESR1 (0.52) | KDM4EMAPTCYP11B2ALDH1A1LMNA | |
| SCHEMBL21782165 | 0.75 | RAB9A (0.55) | KDM4EMAPTHCRTR1CASP1CASP7 | |
| SCHEMBL3853206 | 0.75 | GRIK2 (0.56) | KDM4EMAPTMAOAALDH1A1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200157076-A1 | ACLY INHIBITORS AND USES THEREOF | NIMBUS DISCOVERY, INC. | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200157076-A1 | ACLY INHIBITORS AND USES THEREOF | ACLY, ATP5ME, ATP5MG | KDM4E 1181/4885MAPT 4477/4885HCRTR1 4276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.