Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | EIF4A3 | P38919 | 1/20 | 0.31 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19475598 | 0.87 | EIF4A3 (0.37) | GABRA1GABRG2GABRB3P2RX7EIF4A3 | |
| SCHEMBL25139268 | 0.85 | SIRT1 (0.39) | GABRA1GABRG2GABRB3P2RX7EIF4A3 | |
| SCHEMBL25139377 | 0.84 | GABRA1 (0.33) | GABRA1GABRG2GABRB3P2RX7EIF4A3 | |
| SCHEMBL19507076 | 0.82 | MTNR1A (0.39) | — | |
| SCHEMBL25139023 | 0.80 | GABRA1 (0.35) | GABRA1GABRG2GABRB3POLB | |
| SCHEMBL22015593 | 0.79 | NLRP3 (0.32) | EIF4A3 | |
| SCHEMBL23692145 | 0.78 | SLC9A1 (0.30) | — | |
| SCHEMBL25138925 | 0.76 | SLC9A1 (0.32) | — | |
| SCHEMBL15271468 | 0.72 | CES2 (0.40) | POLBP2RX7 | |
| SCHEMBL30289334 | 0.72 | CES2 (0.40) | POLBP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020102574-A1 | THE COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |