Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Nedocromil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 4/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.39 |
| ▸ | CYSLTR1 | Q9Y271 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 12/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nedocromil SCHEMBL29406688 | 0.95 | PDE5A (0.47) | PDE5AABCB11CYSLTR2CYSLTR1MEN1 | |
| Nedocromil SCHEMBL4611 | 0.95 | PDE5A (0.47) | PDE5AABCB11CYSLTR2CYSLTR1MEN1 | |
| Nedocromil SCHEMBL24943 | 0.94 | PDE5A (0.46) | PDE5AABCB11CYSLTR2CYSLTR1MEN1 | |
| Nedocromil SCHEMBL20481863 | 0.94 | PDE5A (0.46) | PDE5AABCB11CYSLTR2CYSLTR1MEN1 | |
| Nedocromil SCHEMBL28341341 | 0.94 | PDE5A (0.46) | PDE5AABCB11CYSLTR2CYSLTR1MEN1 | |
| Nedocromil SCHEMBL667050 | 0.94 | PDE5A (0.46) | PDE5AABCB11CYSLTR2CYSLTR1MEN1 | |
| Nedocromil SCHEMBL2879046 | 0.94 | PDE5A (0.46) | PDE5AABCB11CYSLTR2CYSLTR1MEN1 | |
| Nedocromil SCHEMBL316743 | 0.94 | PDE5A (0.46) | PDE5AABCB11CYSLTR2CYSLTR1MEN1 | |
| Nedocromil SCHEMBL17274068 | 0.90 | PDE5A (0.44) | PDE5AABCB11CYSLTR2CYSLTR1MEN1 | |
| Nedocromil SCHEMBL17473185 | 0.89 | PDE5A (0.43) | PDE5AABCB11CYSLTR2CYSLTR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023172294-A1 | OPHTHALMIC SUSPENSION VEHICLES AND RELATED METHODS FOR PHARMACEUTICAL INGREDIENT DELIVERY | WILLIS TIMOTHY R (US) | 2023-09-14 | — | — | WO | claimed |
| US-11957702-B2 | Ophthalmic suspension vehicles and related methods for pharmaceutical ingredient delivery | WILLIS TIMOTHY R (US) | 2024-04-16 | — | — | US | disclosed |
| US-20230414646-A1 | OPHTHALMIC SUSPENSION VEHICLES AND RELATED METHODS FOR PHARMACEUTICAL INGREDIENT DELIVERY | WILLIS TIMOTHY R (US) | 2023-12-28 | — | — | US | disclosed |
| US-11771714-B1 | Ophthalmic suspension vehicles and related methods for pharmaceutical ingredient delivery | STONE RALPH P (US) | 2023-10-03 | — | — | US | disclosed |
| US-20230285436-A1 | OPHTHALMIC SUSPENSION VEHICLES AND RELATED METHODS FOR PHARMACEUTICAL INGREDIENT DELIVERY | STONE RALPH P (US) | 2023-09-14 | — | — | US | disclosed |
| WO-2023172294-A1 | OPHTHALMIC SUSPENSION VEHICLES AND RELATED METHODS FOR PHARMACEUTICAL INGREDIENT DELIVERY | WILLIS TIMOTHY R (US) | 2023-09-14 | — | — | WO | disclosed |
| US-20230285437-A1 | OPHTHALMIC SUSPENSION VEHICLES AND RELATED METHODS FOR PHARMACEUTICAL INGREDIENT DELIVERY | WILLIS TIMOTHY R (US) | 2023-09-14 | — | — | US | disclosed |
| US-11752167-B1 | Ophthalmic suspension vehicles and related methods for pharmaceutical ingredient delivery | WILLIS TIMOTHY R (US) | 2023-09-12 | — | — | US | disclosed |
| US-20210386671-A1 | OPHTHALMIC FORMULATIONS PROVIDING DURABLE OCULAR LUBRICATION | EternaTear, Inc. (US) | 2021-12-16 | — | — | US | disclosed |
| EP-3893842-A1 | OPHTHALMIC FORMULATIONS PROVIDING DURABLE OCULAR LUBRICATION | Eternatear, Inc. (US) | 2021-10-20 | — | — | EP | disclosed |
| WO-2020123362-A1 | OPHTHALMIC FORMULATIONS PROVIDING DURABLE OCULAR LUBRICATION | EternaTear, Inc. (US) | 2020-06-18 | — | — | WO | disclosed |
| US-20200179281-A1 | OPHTHALMIC FORMULATIONS PROVIDING DURABLE OCULAR LUBRICATION | EternaTear, Inc. | 2020-06-11 | — | — | US | disclosed |