Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CEPT1 | Q9Y6K0 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3892309 | 0.88 | NPC1 (0.37) | NPC1RAB9AMAPTMEN1KMT2A | |
| Amenamevir SCHEMBL2238614 | 0.87 | HDAC1 (0.37) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL21769884 | 0.87 | USP2 (0.36) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL21769879 | 0.86 | MAPT (0.38) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL21769574 | 0.85 | HCRTR1 (0.31) | HCRTR1HCRTR2CYP3A4 | |
| SCHEMBL21769885 | 0.81 | POLB (0.37) | NPC1RAB9AMAPTSMN1; SMN2HCRTR1 | |
| SCHEMBL21769886 | 0.80 | POLB (0.36) | MAPTHCRTR1HCRTR2NPSR1 | |
| SCHEMBL21769571 | 0.80 | SLC6A9 (0.36) | MAPTNCOA3 | |
| SCHEMBL2239362 | 0.79 | HDAC1 (0.38) | NCOA3 | |
| SCHEMBL2242314 | 0.79 | ALDH1A1 (0.38) | MAPTMEN1KMT2ASMN1; SMN2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020109389-A1 | HELICASE PRIMASE INHIBITORS FOR TREATING CANCER IN A COMBINATION THERAPY WITH ONCOLYTIC VIRUSES | INNOVATIVE MOLECULES GMBH (DE) | 2020-06-04 | — | — | WO | disclosed |