Sugi Predict

Sugi Predict / Compounds / SCHEMBL221022

SCHEMBL221022

SCHEMBL221022

O=C(Cl)c1ccc(-c2ccccc2)o1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 4/20 0.67
▸ HPGD P15428 1/20 0.67
▸ SLC9A1 P19634 1/20 0.57
▸ ERCC5 P28715 1/20 0.57
▸ FEN1 P39748 1/20 0.57
▸ PDE4B Q07343 4/20 0.51
▸ S1PR4 O95977 1/20 0.51
▸ PTPN1 P18031 1/20 0.49
▸ PTPN11 Q06124 1/20 0.49
▸ MAPT P10636 3/20 0.49
▸ MAPK1 P28482 2/20 0.49
▸ SMN1; SMN2 Q16637 2/20 0.49
▸ POLB P06746 2/20 0.49
▸ NR4A1 P22736 1/20 0.49
▸ NR4A2 P43354 1/20 0.49
▸ NR4A3 Q92570 1/20 0.49
▸ NPC1 O15118 1/20 0.49
▸ RAB9A P51151 1/20 0.49
▸ MGAM O43451 1/20 0.48
▸ GAA P10253 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9484980 0.83 ALDH1A1 (0.71) ALDH1A1HPGDSLC9A1ERCC5FEN1
SCHEMBL307282 0.83 ALDH1A1 (0.92) ALDH1A1HPGDSLC9A1ERCC5FEN1
SCHEMBL31462930 0.83 ALDH1A1 (0.42) ALDH1A1HPGDNPSR1KDM4ELMNA
SCHEMBL3325905 0.82 ALDH1A1 (0.61) ALDH1A1HPGDSLC9A1ERCC5FEN1
SCHEMBL28201855 0.81 SLC9A1 (0.59) ALDH1A1HPGDSLC9A1PDE4BPTPN1
SCHEMBL4252554 0.81 ALDH1A1 (0.44) ALDH1A1HPGDSLC9A1ERCC5FEN1
SCHEMBL28511353 0.81 PDE4B (0.52) ALDH1A1HPGDPDE4BMAPTSMN1; SMN2
SCHEMBL9477105 0.81 ALDH1A1 (0.69) ALDH1A1HPGDPDE4BMAPTMAPK1
SCHEMBL3059961 0.80 SLC9A1 (0.65) ALDH1A1HPGDSLC9A1PDE4BS1PR4
SCHEMBL4163540 0.80 ALDH1A1 (0.68) ALDH1A1HPGDSLC9A1ERCC5FEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 103 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109137600-B Preparation method of vanadium-doped antibacterial paper-making material 吴珊珊 2021-08-03 — — CN claimed
CN-116535371-B Guanidine-containing phenyl furan carboxamide compound and application thereof 华南农业大学 2025-02-18 — — CN disclosed
CN-116535371-A Guanidine-containing phenyl furan carboxamide compound and application thereof 华南农业大学 2023-08-04 — — CN disclosed
CN-110294749-B (S) -1, 3-thiazole phenyl furan thiocarbamate compound and preparation method and application thereof 华南农业大学 2022-01-25 — — CN disclosed
CN-109265452-B Substituted phenyl furan-2-mercaptothiazoline ketone compounds and preparation method and application thereof 华南农业大学 2021-08-03 — — CN disclosed
CN-109137600-B Preparation method of vanadium-doped antibacterial paper-making material 吴珊珊 2021-08-03 — — CN disclosed
CN-110183428-B Furan thiocarbamate compound containing 1,2,3, 4-tetrazole and preparation method and application thereof 华南农业大学 2021-08-03 — — CN disclosed
CN-107674070-B Cyanoimine thiazolidine furan carboxamide compound and preparation method and application thereof 华南农业大学 2020-12-29 — — CN disclosed
US-20200095217-A1 HYDROXY FORMAMIDE DERIVATIVES AND THEIR USE GLAXOSMITHKLINE IP NO 2 LTD (GB) 2020-03-26 — — US disclosed
US-10450288-B2 Hydroxy formamide derivatives and their use GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED (GB) 2019-10-22 — — US disclosed
WO-2007019346-A1 BENZOTHIAZOLES AND THIAZOLOPYRIDINES AS SIRTUIN MODULATORS SIRTRIS PHARMACEUTICALS, INC. (US) 2007-02-15 — — WO disclosed
WO-2007019346-A1 BENZOTHIAZOLES AND THIAZOLOPYRIDINES AS SIRTUIN MODULATORS SIRTRIS PHARMACEUTICALS, INC. (US) 2007-02-15 — — WO disclosed
WO-2007019344-A1 IMIDAZO [2,1-B] THIAYOLE DERIVATIVES AS SIRTUIN MODULATING COMPOUNDS SIRTRIS PHARMACEUTICALS, INC. (US) 2007-02-15 — — WO disclosed
WO-2007019344-A1 IMIDAZO [2,1-B] THIAYOLE DERIVATIVES AS SIRTUIN MODULATING COMPOUNDS SIRTRIS PHARMACEUTICALS, INC. (US) 2007-02-15 — — WO disclosed
US-5214042-A Use of 5-phenyl-2-furan esters, amides and ketones as neuroprotective agents NORWICH EATON PHARMACEUTICALS, INC. (US) 1993-05-25 — — US disclosed
US-5118708-A USE OF 5-PHENYL-2-FURAN ESTERS, AMIDES AND KETONES AS NEUROPROTECTIVE AGENTS NORWICH EATON PHARMACEUTICALS, INC. (US) 1992-06-02 — — US disclosed
US-5023272-A Use of 5-phenyl-2-furan esters and amides as antiepileptic agents NORWICH EATON PHARMACEUTICALS, INC. (US) 1991-06-11 — — US disclosed
EP-0404231-A1 The use of 5-phenyl-2 furan esters and amides as antiepileptic agents Norwich Eaton Pharmaceuticals, Inc. (US) 1990-12-27 — — EP disclosed
EP-0404233-A2 Novel use of 5-phenyl-2-furan esters, amides and ketones as neuroprotective agents Norwich Eaton Pharmaceuticals, Inc. (US) 1990-12-27 — — EP disclosed
US-4162257-A N,N-dimethyl-5-phenyl-2-furamides MORTON-NORWICH PRODUCTS, INC. (US) 1979-07-24 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200095217-A1 HYDROXY FORMAMIDE DERIVATIVES AND THEIR USE BMP1, BMPR1A, BMPR2 ALDH1A1 471/4885HPGD 1224/4885SLC9A1 483/4885
US-10450288-B2 Hydroxy formamide derivatives and their use BMP1, BMPR1A, BMPR2 ALDH1A1 471/4885HPGD 1224/4885SLC9A1 483/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.