Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | RGS4 | P49798 | 1/20 | 0.30 |
| ▸ | RGS8 | P57771 | 1/20 | 0.30 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
| ▸ | TYMS | P04818 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22105455 | 0.80 | KMT2A (0.33) | ALDH1A1KMT2APDE5AHTTLMNA | |
| SCHEMBL22111429 | 0.77 | P2RX3 (0.34) | P2RX3KMT2APDE5ANPSR1RGS4 | |
| SCHEMBL22105780 | 0.74 | ALDH1A1 (0.38) | ALDH1A1KMT2AHTTLMNA | |
| SCHEMBL22105371 | 0.71 | TPH1 (0.50) | ALDH1A1KMT2ANPSR1HTTLMNA | |
| SCHEMBL22105360 | 0.66 | PDE5A (0.37) | PDE5A | |
| SCHEMBL22105783 | 0.65 | BRD4 (0.50) | ALDH1A1KMT2ANPSR1HTTPOLB | |
| SCHEMBL22105573 | 0.64 | KDM4E (0.55) | ALDH1A1KMT2ANPSR1HTTPOLB | |
| SCHEMBL22105567 | 0.61 | TSHR (0.45) | ALDH1A1 | |
| SCHEMBL19505598 | 0.58 | NOD1 (0.32) | ALDH1A1KMT2APDE5AHTTLMNA | |
| SCHEMBL20432069 | 0.58 | TRPC5 (0.36) | ALDH1A1P2RX3KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11198696-B2 | Substituted xanthines as inhibitors of transient receptor potential cation channel subfamily c, member 5 activity | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-12-14 | — | — | US | disclosed |
| US-20200190093-A1 | SUBSTITUTED XANTHINE DERIVATIVES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2020-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200190093-A1 | SUBSTITUTED XANTHINE DERIVATIVES | TRPC5, TRPC4, TRPM5 | ALDH1A1 869/4885P2RX3 9/4885KMT2A 4474/4885 |
| US-11198696-B2 | Substituted xanthines as inhibitors of transient receptor potential cation channel subfamily c, member 5 activity | TRPC5, TRPM5, TRPC4 | ALDH1A1 1568/4885P2RX3 24/4885KMT2A 4085/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.