Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 6/20 | 0.45 |
| ▸ | NOS3 | P29474 | 4/20 | 0.45 |
| ▸ | NOS1 | P29475 | 2/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2718532 | 0.83 | NOS3 (0.48) | NOS2NOS3NOS1HSP90AA1HSP90AB1 | |
| SCHEMBL31493035 | 0.79 | NOS3 (0.45) | NOS2NOS3NOS1HSP90AA1HSP90AB1 | |
| SCHEMBL16840978 | 0.77 | HSP90AA1 (0.48) | NOS2NOS3NOS1HSP90AA1HSP90AB1 | |
| SCHEMBL14842309 | 0.75 | NOS2 (0.50) | NOS2NOS3NOS1HSP90AA1HSP90AB1 | |
| SCHEMBL11403178 | 0.71 | MAPT (0.47) | NOS2NOS3NOS1HSP90AA1HSP90AB1 | |
| SCHEMBL28114191 | 0.69 | — | — | |
| SCHEMBL687645 | 0.67 | — | — | |
| SCHEMBL30037427 | 0.67 | — | — | |
| SCHEMBL879566 | 0.67 | — | — | |
| SCHEMBL30041346 | 0.67 | NOS3 (0.34) | NOS2NOS3NOS1HSP90AA1NUDT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260098029-A1 | KIF18A INHIBITORS | AMGEN INC. (US) | 2026-04-09 | — | — | US | disclosed |
| US-12509442-B2 | KIF18A inhibitors | AMGEN INC. (US) | 2025-12-30 | — | — | US | disclosed |
| CN-113226473-B | KIF18A inhibitors | 美国安进公司 | 2025-05-13 | — | — | CN | disclosed |
| US-20240317715-A1 | KIF18A INHIBITORS | AMGEN INC. (US) | 2024-09-26 | — | — | US | disclosed |
| US-12054476-B2 | KIF18A inhibitors | AMGEN INC. (US) | 2024-08-06 | — | — | US | disclosed |
| US-20220106293-A1 | KIF18A INHIBITORS | AMGEN INC. (US) | 2022-04-07 | — | — | US | disclosed |
| US-11236069-B2 | KIF18A inhibitors | AMGEN INC. (US) | 2022-02-01 | — | — | US | disclosed |
| US-11236069-B2 | KIF18A inhibitors | AMGEN INC. (US) | 2022-02-01 | — | — | US | disclosed |
| EP-3897852-A1 | KIF18A INHIBITORS | Amgen Inc. (US) | 2021-10-27 | — | — | EP | disclosed |
| CN-113226473-A | KIF18A inhibitors | 美国安进公司 | 2021-08-06 | — | — | CN | disclosed |
| US-20200239441-A1 | KIF18A INHIBITORS | AMGEN INC. (US) | 2020-07-30 | — | — | US | disclosed |
| US-20200239441-A1 | KIF18A INHIBITORS | AMGEN INC. (US) | 2020-07-30 | — | — | US | disclosed |
| WO-2020132648-A1 | KIF18A INHIBITORS | AMGEN INC. (US) | 2020-06-25 | — | — | WO | disclosed |
| WO-2020132648-A1 | KIF18A INHIBITORS | AMGEN INC. (US) | 2020-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12509442-B2 | KIF18A inhibitors | KIF18A, KIF18B, KIFC1 | NOS2 4797/4885NOS3 4479/4885NOS1 4464/4885 |
| US-20240317715-A1 | KIF18A INHIBITORS | KIF18A, KIF18B, KIF15 | NOS2 4315/4885NOS3 4245/4885NOS1 3907/4885 |
| US-20220106293-A1 | KIF18A INHIBITORS | KIF18A, KIF18B, KIF15 | NOS2 4315/4885NOS3 4245/4885NOS1 3907/4885 |
| US-20200239441-A1 | KIF18A INHIBITORS | KIF18A, KIF18B, KIF15 | NOS2 4315/4885NOS3 4245/4885NOS1 3907/4885 |
| US-12054476-B2 | KIF18A inhibitors | KIF18A, KIF18B, KIF15 | NOS2 4315/4885NOS3 4245/4885NOS1 3907/4885 |
| US-20260098029-A1 | KIF18A INHIBITORS | KIF18A, KIF18B, KIFC1 | NOS2 4800/4885NOS3 4461/4885NOS1 4451/4885 |
| US-11236069-B2 | KIF18A inhibitors | KIF18A, KIF18B, KIF15 | NOS2 4315/4885NOS3 4245/4885NOS1 3907/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.