Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | BRD4 | O60885 | 2/20 | 0.46 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.46 |
| ▸ | EP300 | Q09472 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22137275 | 0.87 | ALDH1A1 (0.54) | MAPK1HPGDBRD4BRPF1CREBBP | |
| SCHEMBL22137276 | 0.79 | BRD4 (0.42) | MAPK1NPSR1BRD4BRPF1CREBBP | |
| SCHEMBL8203697 | 0.74 | HPGD (0.59) | MAPK1HPGDNPSR1SMN1; SMN2MAPT | |
| SCHEMBL7482811 | 0.71 | NPSR1 (0.62) | MAPK1HPGDNPSR1BRD4BRPF1 | |
| SCHEMBL22137286 | 0.71 | ALDH1A1 (0.55) | MAPK1HPGDNPSR1BRD4BRPF1 | |
| SCHEMBL8204552 | 0.69 | BRD4 (0.62) | MAPK1HPGDBRD4BRPF1CREBBP | |
| SCHEMBL29953002 | 0.67 | BRD4 (0.51) | MAPK1HPGDNPSR1BRD4BRPF1 | |
| SCHEMBL24263944 | 0.67 | LMNA (0.47) | MAPK1HPGDNPSR1SMN1; SMN2CYP1A2 | |
| SCHEMBL7256405 | 0.67 | NPSR1 (0.79) | MAPK1HPGDNPSR1SMN1; SMN2MAPT | |
| SCHEMBL13919303 | 0.66 | IGF1R (0.61) | MAPK1NPSR1BRD4BRPF1CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3898587-B1 | CONDENSED PYRROLES AS NOVEL BROMODOMAIN INHIBITORS | UNIV FREIBURG ALBERT LUDWIGS (DE) | 2024-06-26 | — | — | EP | disclosed |
| WO-2020127846-A9 | CONDENSED PYRROLES AS NOVEL BROMODOMAIN INHIBITORS | ALBERT LUDWIG UNIVERSITÄT FREIBURG (DE) | 2021-08-12 | — | — | WO | disclosed |
| WO-2020127846-A1 | CONDENSED PYRROLES AS NOVEL BROMODOMAIN INHIBITORS | ALBERT LUDWIG UNIVERSITÄT FREIBURG (DE) | 2020-06-25 | — | — | WO | disclosed |