Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MYLK | Q15746 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22145138 | 0.89 | KDM4E (0.38) | KDM4EHPGDALDH1A1HSD17B10MAPT | |
| SCHEMBL22145201 | 0.87 | MAPT (0.36) | KDM4EHPGDALDH1A1HTTHSD17B10 | |
| SCHEMBL22145205 | 0.86 | EDNRA (0.34) | KDM4EHPGDALDH1A1L3MBTL1HTT | |
| SCHEMBL22145135 | 0.84 | EDNRA (0.36) | KDM4EHPGDALDH1A1MAPTMEN1 | |
| SCHEMBL22145207 | 0.84 | KDM4E (0.33) | KDM4EHPGDALDH1A1L3MBTL1HTT | |
| SCHEMBL22145210 | 0.83 | ALDH1A1 (0.31) | KDM4EHPGDALDH1A1HTTHSD17B10 | |
| SCHEMBL22145211 | 0.81 | POLB (0.31) | MAPTPOLB | |
| SCHEMBL22145126 | 0.81 | PPARG (0.38) | HPGDALDH1A1L3MBTL1MAPTPOLB | |
| SCHEMBL22145250 | 0.80 | KDM4E (0.36) | KDM4EHPGDALDH1A1L3MBTL1HTT | |
| SCHEMBL22145204 | 0.80 | L3MBTL1 (0.31) | KDM4EHPGDALDH1A1L3MBTL1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3898636-B9 | INDOLONAPHTHOPYRANS | TRANSITIONS OPTICAL LTD (IE) | 2023-11-08 | — | — | EP | disclosed |
| EP-3898636-B1 | INDOLONAPHTHOPYRANS | TRANSITIONS OPTICAL LTD (IE) | 2023-08-30 | — | — | EP | disclosed |
| US-20220056039-A1 | Indolonaphthopyrans | TRANSITIONS OPTICAL, LTD. (IE) | 2022-02-24 | — | — | US | disclosed |
| US-20210317129-A1 | Indolenaphthopyrans | TRANSITIONS OPTICAL, LTD. (IE) | 2021-10-14 | — | — | US | disclosed |
| WO-2020126032-A1 | INDOLONAPHTHOPYRANS | TRANSITIONS OPTICAL, LTD. (IE) | 2020-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210317129-A1 | Indolenaphthopyrans | AHR, TDO2, TPH2 | KDM4E 3276/4885HPGD 2147/4885ALDH1A1 953/4885 |
| US-20220056039-A1 | Indolonaphthopyrans | TPH1, TPH2, IDO1 | KDM4E 3356/4885HPGD 1161/4885ALDH1A1 230/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.