SCHEMBL221482

SCHEMBL221482

C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(OC(=O)CCC(=O)O)C(=O)CO

nearest known ligand 0.86

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
NR3C2 P08235 8/20 0.86
PGR P06401 4/20 0.86
NR3C1 P04150 3/20 0.86
HIF1A Q16665 9/20 0.85
KMT2A Q03164 2/20 0.85
SMN1; SMN2 Q16637 2/20 0.69
AR P10275 3/20 0.68
CHRM1 P11229 2/20 0.68
CYP2C19 P33261 2/20 0.67
HSD17B10 Q99714 2/20 0.67
NFKB1 P19838 2/20 0.67
SERPINA6 P08185 2/20 0.67
SHBG P04278 1/20 0.67
CYP3A4 P08684 1/20 0.67
MAPT P10636 1/20 0.67
PMP22 Q01453 1/20 0.58
TSHR P16473 1/20 0.58
LMNA P02545 2/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29060653 1.00 NR3C2 (0.86) NR3C2PGRNR3C1HIF1AKMT2A
SCHEMBL10597451 0.94 NR3C2 (0.87) NR3C2PGRNR3C1HIF1AKMT2A
SCHEMBL10597455 0.94 NR3C2 (0.87) NR3C2PGRNR3C1HIF1AKMT2A
Hydrocortisone Butyrate SCHEMBL14936050 0.92 NR3C2 (1.00) NR3C2PGRNR3C1HIF1AKMT2A
Hydrocortisone Butyrate SCHEMBL21111521 0.92 NR3C2 (1.00) NR3C2PGRNR3C1HIF1AKMT2A
Hydrocortisone Butyrate SCHEMBL14339600 0.92 NR3C2 (1.00) NR3C2PGRNR3C1HIF1AKMT2A
Hydrocortisone Butyrate SCHEMBL111478 0.92 NR3C2 (1.00) NR3C2PGRNR3C1HIF1AKMT2A
Hydrocortisone Butyrate SCHEMBL14473210 0.92 NR3C2 (1.00) NR3C2PGRNR3C1HIF1AKMT2A
Hydrocortisone Butyrate SCHEMBL4695 0.92 NR3C2 (1.00) NR3C2PGRNR3C1HIF1AKMT2A
Hydrocortisone Butyrate SCHEMBL11209085 0.92 NR3C2 (1.00) NR3C2PGRNR3C1HIF1AKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 927 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250152705-A1 COMBINATION THERAPY COMPRISING AN ANTI-IL-23 ANTIBODY AND A CORTICOSTEROID FOR TREATING PSORIASIS SUN PHARMACEUTICAL INDUSTRIES LIMITED (IN) 2025-05-15 US claimed
CN-119657043-A Device and method for preparing hydrocortisone sodium succinate 西安国康瑞金制药有限公司 2025-03-21 CN claimed
CN-117257742-B Preparation method of hydrocortisone sodium succinate freeze-dried powder injection for injection 烟台东诚北方制药有限公司 2025-03-04 CN claimed
CN-119464390-A Method for constructing human umbilical vein endothelial cell model of trans-mitochondria 浙江大学 2025-02-18 CN claimed
CN-119265038-A Vascularized tissue culture chip and construction method and application thereof 武汉市中西医结合医院(武汉市第一医院) 2025-01-07 CN claimed
US-20240408110-A1 PHARMACEUTICAL HYDROCORTISONE SOLUTION FOR INJECTION DEVICE CROSSJECT (FR) 2024-12-12 US claimed
EP-4463228-A1 COMBINATION THERAPY COMPRISING AN ANTI-IL-23 ANTIBODY AND A CORTICOSTEROID FOR TREATING PSORIASIS Sun Pharmaceutical Industries Limited (IN) 2024-11-20 EP claimed
CN-118935929-A Preparation method and device of hydrocortisone sodium succinate injection 西安国康瑞金制药有限公司 2024-11-12 CN claimed
EP-4429634-A1 PHARMACEUTICAL SOLUTION OF HYDROCORTISONE FOR INJECTION DEVICE Crossject (FR) 2024-09-18 EP claimed
CN-118251209-A Hydrocortisone pharmaceutical solution for injection device 克鲁斯杰克特公司 2024-06-25 CN claimed
US-20050004098-A1 Dispersible formulation of an anti-inflammatory agent BRITTEN NANCY JEAN (US) 2005-01-06 US claimed
US-20040235803-A1 Dispersible formulation of an anti-inflammatory agent PHARMACIA & UPJOHN COMPANY 2004-11-25 US claimed
US-20040214753-A1 Dispersible pharmaceutical composition for treatment of mastitis and otic disorders PHARMACIA & UPJOHN COMPANY 2004-10-28 US claimed
WO-2004082719-A1 DISPERSIBLE PHARMACEUTICAL COMPOSITION FOR TREATMENT OF MASTITIS AND OTIC DISORDERS PHARMACIA CORPORATION (US) 2004-09-30 WO claimed
WO-2004082588-A2 DISPERSIBLE FORMULATION OF AN ANTI-INFLAMMATORY AGENT PHARMACIA CORPORATION (US) 2004-09-30 WO claimed
US-6324424-B1 Reduction of skin irritation during electrotransport delivery ALZA CORPORATION 2001-11-27 US claimed
EP-0752898-B1 REDUCTION OF SKIN IRRITATION DURING ELECTROTRANSPORT DELIVERY ALZA CORP (US) 1998-04-29 EP claimed
WO-1998012304-A1 CULTURE SYSTEM FOR HEMATOPOIETIC STEM CELLS MEDICAL RESEARCH COUNCIL (GB) 1998-03-26 WO claimed
EP-0752898-A1 REDUCTION OF SKIN IRRITATION DURING ELECTROTRANSPORT DELIVERY ALZA CORPORATION (US) 1997-01-15 EP claimed
WO-1995026782-A1 REDUCTION OF SKIN IRRITATION DURING ELECTROTRANSPORT DELIVERY ALZA CORPORATION (US) 1995-10-12 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040235803-A1 Dispersible formulation of an anti-inflammatory agent TNF, LTB4R2, LTA NR3C2 825/4885PGR 1196/4885NR3C1 1402/4885
US-20050004098-A1 Dispersible formulation of an anti-inflammatory agent TNF, IL6, IL1A NR3C2 1790/4885PGR 1663/4885NR3C1 2938/4885
US-20040214753-A1 Dispersible pharmaceutical composition for treatment of mastitis and otic disorders OTC, AQP3, AQP1 NR3C2 1219/4885PGR 541/4885NR3C1 2612/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.