Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABBR2 | O75899 | 4/20 | 0.38 |
| ▸ | GABBR1 | Q9UBS5 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CTSA | P10619 | 6/20 | 0.36 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2217025 | 0.76 | FOLH1 (0.34) | LMNACYP3A4NFKB1CYP1A2CYP2D6 | |
| SCHEMBL15061221 | 0.71 | KMT2A (0.49) | LMNACYP2C9CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL939692 | 0.70 | FABP4 (0.39) | LMNACYP2C9CYP1A2NAPRTL3MBTL1 | |
| SCHEMBL6581667 | 0.70 | GABBR2 (0.51) | GABBR2GABBR1LMNACYP2C9CYP3A4 | |
| SCHEMBL9722631 | 0.70 | CYP3A4 (0.36) | LMNACYP3A4ADORA3NFKB1BLM | |
| SCHEMBL2217027 | 0.69 | MEN1 (0.32) | MEN1KMT2ANAPRT | |
| SCHEMBL2737360 | 0.69 | GABRA1 (0.37) | LMNA | |
| SCHEMBL7142534 | 0.68 | AKR1C4 (0.47) | GABBR2GABBR1LMNACYP2C9CYP3A4 | |
| SCHEMBL29411268 | 0.67 | ALDH1A1 (0.47) | LMNAMEN1TSHRKMT2ANAPRT | |
| SCHEMBL1300053 | 0.67 | ALDH1A1 (0.47) | LMNAMEN1TSHRKMT2ANAPRT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1709046-B1 | P38 KINASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2011-07-27 | — | — | EP | disclosed |