SCHEMBL221809

SCHEMBL221809

COC(=O)CC(=O)C1CC1

nearest known ligand 0.46

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.46
MGAM O43451 1/20 0.46
SI P14410 1/20 0.46
MGAM2 Q2M2H8 1/20 0.46
TSHR P16473 4/20 0.43
HSD17B10 Q99714 2/20 0.40
SMN1; SMN2 Q16637 1/20 0.39
EPHX2 P34913 3/20 0.37
CA12 O43570 1/20 0.37
CA14 Q9ULX7 1/20 0.37
TET2 Q6N021 1/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
BRD4 O60885 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20599735 0.91 TP53 (0.43) GAAMGAMSIMGAM2TSHR
SCHEMBL21987187 0.91 TP53 (0.43) GAAMGAMSIMGAM2TSHR
SCHEMBL1017827 0.91 MGAM (0.42) GAAMGAMSIMGAM2TSHR
SCHEMBL1013082 0.91 EPHX2 (0.43) GAAMGAMSIMGAM2TSHR
SCHEMBL6710648 0.89 GAA (0.41) GAAMGAMSIMGAM2TSHR
SCHEMBL1014784 0.89 EPHX2 (0.46) GAAMGAMSIMGAM2TSHR
SCHEMBL17525561 0.89 EPHX2 (0.46) GAAMGAMSIMGAM2TSHR
SCHEMBL20599527 0.86 SMN1; SMN2 (0.45) GAAMGAMSIMGAM2SMN1; SMN2
SCHEMBL3594828 0.85 GLA (0.39) GAAMGAMSIMGAM2TSHR
SCHEMBL20599690 0.83 CHRNB2 (0.40) GAAMGAMSIMGAM2TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 791 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2387561-A2 IMPROVED PROCESS FOR THE PREPARATION OF HIGHLY PURE (3R,5S)-7-Ý2-CYCLOPROPYL-4-(4-FLUOROPHENYL) QUINOLIN-3-YL¨-3,5-DIHYDROXY-6(E)-HEPTENOIC ACID AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF MSN Laboratories Limited (IN) 2011-11-23 EP claimed
WO-2010089770-A2 IMPROVED PROCESS FOR THE PREPARATION OF HIGHLY PURE (3R,5S)-7-[2-CYCLOPROPYL-4-(4-FLUOROPHENYL) QUINOLIN-3-YL]-3,5-DIHYDROXY-6(E)-HEPTENOIC ACID AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF MSN LABORATORIES LIMITED (IN) 2010-08-12 WO claimed
EP-1261657-B1 POLY(3-CYCLOPROPYL-3-HYDROXYPROPIONATE) AND PROCESSES FOR ITS PREPARATION AND DERIVATIVES THEREOF EASTMAN CHEM CO (US) 2004-11-10 EP claimed
US-20030212294-A1 Poly(3-cyclopropyl-3-hydroxypropionate) and processes for its preparation and derivatives thereof HUBBS JOHN CLARK (US) 2003-11-13 US claimed
US-20030208092-A1 Poly(3-cyclopropyl-3-hydroxypropionate) and processes for its preparation and derivatives thereof HUBBS JOHN CLARK (US) 2003-11-06 US claimed
JP-2003518519-A 2003-06-10 JP claimed
EP-1261657-A2 POLY(3-CYCLOPROPYL-3-HYDROXYPROPIONATE) AND PROCESSES FOR ITS PREPARATION AND DERIVATIVES THEREOF EASTMAN CHEMICAL COMPANY (US) 2002-12-04 EP claimed
US-6441176-B1 N-(5-CYCLOPROPYL-1-QUINOLIN-5-YL-1H-PYRAZOLE-4-CARBONYL) -GUANIDINE; REACTING QUINOLIN-5-YL-HYDRAZINE AND METHYL-3-CYCLOPROPYL-2-DIMETHYLENAMINO-3-OXOPROPANOATE, HYDROYLZING, FORMING ACYLHALIDE AND FURTHER REACTING WITH GUANIDINE PFIZER INC. 2002-08-27 US claimed
EP-1101763-A2 Method for preparing sodium-hydrogen exchanger type 1 inhibitor Pfizer Products Inc. (US) 2001-05-23 EP claimed
WO-2000068290-A2 POLY(3-CYCLOPROPYL-3-HYDROXYPROPIONATE) AND PROCESSES FOR ITS PREPARATION AND DERIVATIVES THEREOF EASTMAN CHEMICAL COMPANY (US) 2000-11-16 WO claimed
EP-4744661-A2 NOVEL PYRIMIDIN-2-YL SULFONAMIDE DERIVATIVES F. Hoffmann-La Roche AG (CH) 2026-05-20 EP disclosed
EP-4731262-A1 PHARMACEUTICAL COMPOSITION COMPRISING A QUINAZOLINE COMPOUND Astellas Pharma Inc. (JP) 2026-04-29 EP disclosed
US-12611401-B2 Combinations comprising benzodioxol as GLP-1R agonists for use in the treatment of NASH/NAFLD and related diseases PFIZER INC. (US) 2026-04-28 US disclosed
US-20260070896-A1 HETEROCYCLE DERIVATIVES FOR TREATING TRPM3 MEDIATED DISORDERS UNIV LEUVEN KATH (BE) 2026-03-12 US disclosed
US-12570666-B2 Furoindazole derivatives BAYER AKTIENGESELLSCHAFT (DE) 2026-03-10 US disclosed
WO-1998052944-A1 HETEROARYLCARBOXAMIDE COMPOUNDS ACTIVE AGAINST PROTEIN TYROSINE KINASE RELATED DISORDERS SUGEN, INC. (US) 1998-11-26 WO disclosed
EP-0378850-B1 Substituted pyrido(2,3-d) pyrimidines BAYER AG (DE) 1994-04-06 EP disclosed
US-5145959-A Enzyme inhibitors; antilipemic agents; treatment of atherosclerosis BAYER AKTIENGESELLSCHAFT (DE) 1992-09-08 US disclosed
US-5075311-A Anticholesterol agents BAYER AKTIENGESELLSCHAFT (DE) 1991-12-24 US disclosed
US-4829076-A CARDIOVASCULAR DISORDERS ALKALOIDA VEGYESZETI GYAR (HU) 1989-05-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030212294-A1 Poly(3-cyclopropyl-3-hydroxypropionate) and processes for its preparation and derivatives thereof HACL2, HPD, GRHPR GAA 1126/4885MGAM 592/4885SI 72/4885
US-20030208092-A1 Poly(3-cyclopropyl-3-hydroxypropionate) and processes for its preparation and derivatives thereof HPD, HACL2, GRHPR GAA 1073/4885MGAM 625/4885SI 69/4885
US-12570666-B2 Furoindazole derivatives FURIN, CYP2F1, CYP3A7 GAA 599/4885MGAM 2228/4885SI 555/4885
US-12611401-B2 Combinations comprising benzodioxol as GLP-1R agonists for use in the treatment of NASH/NAFLD and related diseases GLP1R, GCKR, GPR119 GAA 973/4885MGAM 3303/4885SI 2991/4885
US-20260070896-A1 HETEROCYCLE DERIVATIVES FOR TREATING TRPM3 MEDIATED DISORDERS TRPM6, TRPV3, TRPM2 GAA 4364/4885MGAM 4372/4885SI 3379/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.