Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 9/20 | 0.38 |
| ▸ | BCR | P11274 | 8/20 | 0.38 |
| ▸ | SRC | P12931 | 4/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | PRKACG | P22612 | 1/20 | 0.38 |
| ▸ | PRKACB | P22694 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | PRKCA | P17252 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22201400 | 0.90 | KMT2A (0.37) | ABL1BCRSRCMAPTNPC1 | |
| SCHEMBL22201260 | 0.87 | ABL1 (0.39) | ABL1BCRSRCEGFRPRKACA | |
| SCHEMBL22201288 | 0.87 | ABL1 (0.39) | ABL1BCRSRCEGFRPRKACA | |
| SCHEMBL22201287 | 0.87 | ABL1 (0.39) | ABL1BCRSRCEGFRPRKACA | |
| SCHEMBL22201277 | 0.87 | PRKCA (0.42) | ABL1BCRSRCEGFRPRKACA | |
| SCHEMBL22201304 | 0.86 | SYK (0.43) | NPC1RAB9ASMN1; SMN2LMNAP2RX3 | |
| SCHEMBL22201328 | 0.85 | ABL1 (0.38) | ABL1BCRSRCEGFRPRKACA | |
| SCHEMBL22201526 | 0.84 | ABL1 (0.35) | ABL1BCRSRCEGFRPRKACA | |
| SCHEMBL22201522 | 0.84 | ROCK2 (0.39) | ABL1BCRSRCEGFRPRKACA | |
| SCHEMBL22201366 | 0.84 | MAPT (0.39) | ABL1BCRSRCEGFRPRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142748-A1 | METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-07-09 | — | — | WO | disclosed |