Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | THPO | P40225 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.40 |
| ▸ | ITGA4 | P13612 | 3/20 | 0.40 |
| ▸ | ICMT | O60725 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | GNPAT | O15228 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | PRNP | P04156 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12442318 | 1.00 | MAPT (0.47) | MAPTALOX15KDM4ETHRBNFKB1 | |
| SCHEMBL308083 | 0.87 | MAPT (0.59) | MAPTALOX15KDM4ETHRBNFKB1 | |
| SCHEMBL308082 | 0.87 | MAPT (0.59) | MAPTALOX15KDM4ETHRBNFKB1 | |
| SCHEMBL25329304 | 0.87 | MAPT (0.59) | MAPTALOX15KDM4ETHRBNFKB1 | |
| SCHEMBL2140974 | 0.87 | MAPT (0.59) | MAPTALOX15KDM4ETHRBNFKB1 | |
| SCHEMBL24067699 | 0.87 | MAPT (0.59) | MAPTALOX15KDM4ETHRBNFKB1 | |
| SCHEMBL4668974 | 0.86 | MAPT (0.57) | MAPTALOX15KDM4ETHRBNFKB1 | |
| SCHEMBL4668975 | 0.86 | MAPT (0.57) | MAPTALOX15KDM4ETHRBNFKB1 | |
| Water SCHEMBL8124987 | 0.85 | MAPT (0.57) | MAPTALOX15KDM4ETHRBNFKB1 | |
| SCHEMBL25340359 | 0.85 | MAPT (0.57) | MAPTALOX15KDM4ETHRBNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130165515-A1 | Organosulfur Compounds for the Prevention and Treatment of Neurodegenerative Diseases | ALLIUM VITALIS INC. | 2013-06-27 | — | — | US | claimed |
| US-20130143967-A1 | Organosulfur compounds for the prevention and treatment of neurodegenerative diseases | ALLIUM VITALIS INC. | 2013-06-06 | — | — | US | claimed |
| US-8455552-B2 | Composition comprising S-allylmercapto-N-acetylcysteine (ASSNAC) for up-regulation of cellular glutathione level | Ramot et Tel Aviv University Ltd. (IL) | 2013-06-04 | — | — | US | claimed |
| US-20120295977-A1 | Organosulfur prodrugs for the prevention and treatment of infectious diseases | OTT DAVID M (US) | 2012-11-22 | — | — | US | claimed |
| EP-2139465-B1 | COMPOSITION COMPRISING S-ALLYLMERCAPTO-N-ACETYLCYSTEINE (ASSNAC) FOR UP-REGULATION OF CELLULAR GLUTATHIONE LEVEL | UNIV RAMOT (IL) | 2012-09-26 | — | — | EP | claimed |
| US-20110178152-A1 | COMPOSITION COMPRISING S-ALLYLMERCAPTO-N-ACETYLCYSTEINE (ASSNAC) FOR UP-REGULATION OF CELLULAR GLUTATHIONE LEVEL | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2011-07-21 | — | — | US | claimed |
| EP-2139465-A1 | COMPOSITION COMPRISING S-ALLYLMERCAPTO-N-ACETYLCYSTEINE (ASSNAC) FOR UP-REGULATION OF CELLULAR GLUTATHIONE LEVEL | Ramot at Tel-Aviv University Ltd. (IL) | 2010-01-06 | — | — | EP | claimed |
| WO-2008135984-A1 | COMPOSITION COMPRISING S-ALLYLMERCAPTO-N-ACETYLCYSTEINE (ASSNAC) FOR UP-REGULATION OF CELLULAR GLUTATHIONE LEVEL | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2008-11-13 | — | — | WO | claimed |
| US-10758498-B2 | Method of decreasing protein-aldehyde adducts by administering a mixed disulfide of n-acetylcysteine and propyl mercaptan, propenyl mercaptan, or allyl mercaptan | SOCTRONICS TECHNOLOGIES PRIVATE LIMITED (IN) | 2020-09-01 | — | — | US | disclosed |
| US-10758498-B2 | Method of decreasing protein-aldehyde adducts by administering a mixed disulfide of n-acetylcysteine and propyl mercaptan, propenyl mercaptan, or allyl mercaptan | SOCTRONICS TECHNOLOGIES PRIVATE LIMITED (IN) | 2020-09-01 | — | — | US | disclosed |
| US-10258581-B2 | Organosulfur compounds for the prevention and treatment of neurodegenerative diseases | OTT DAVID MICHAEL (US) | 2019-04-16 | — | — | US | disclosed |
| US-10258581-B2 | Organosulfur compounds for the prevention and treatment of neurodegenerative diseases | OTT DAVID MICHAEL (US) | 2019-04-16 | — | — | US | disclosed |
| US-20190076377-A1 | ORGANOSULFUR COMPOUNDS FOR THE PREVENTION AND TREATMENT OF NEURODEGENERATIVE DISEASES | SOCTRONICS TECHNOLOGIES PRIVATE LIMITED (IN) | 2019-03-14 | — | — | US | disclosed |
| US-20190076377-A1 | ORGANOSULFUR COMPOUNDS FOR THE PREVENTION AND TREATMENT OF NEURODEGENERATIVE DISEASES | SOCTRONICS TECHNOLOGIES PRIVATE LIMITED (IN) | 2019-03-14 | — | — | US | disclosed |
| US-20110178152-A1 | COMPOSITION COMPRISING S-ALLYLMERCAPTO-N-ACETYLCYSTEINE (ASSNAC) FOR UP-REGULATION OF CELLULAR GLUTATHIONE LEVEL | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2011-07-21 | — | — | US | disclosed |
| US-20110178152-A1 | COMPOSITION COMPRISING S-ALLYLMERCAPTO-N-ACETYLCYSTEINE (ASSNAC) FOR UP-REGULATION OF CELLULAR GLUTATHIONE LEVEL | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2011-07-21 | — | — | US | disclosed |
| EP-2139465-A1 | COMPOSITION COMPRISING S-ALLYLMERCAPTO-N-ACETYLCYSTEINE (ASSNAC) FOR UP-REGULATION OF CELLULAR GLUTATHIONE LEVEL | Ramot at Tel-Aviv University Ltd. (IL) | 2010-01-06 | — | — | EP | disclosed |
| EP-2139465-A1 | COMPOSITION COMPRISING S-ALLYLMERCAPTO-N-ACETYLCYSTEINE (ASSNAC) FOR UP-REGULATION OF CELLULAR GLUTATHIONE LEVEL | Ramot at Tel-Aviv University Ltd. (IL) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008135984-A1 | COMPOSITION COMPRISING S-ALLYLMERCAPTO-N-ACETYLCYSTEINE (ASSNAC) FOR UP-REGULATION OF CELLULAR GLUTATHIONE LEVEL | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2008-11-13 | — | — | WO | disclosed |
| WO-2008135984-A1 | COMPOSITION COMPRISING S-ALLYLMERCAPTO-N-ACETYLCYSTEINE (ASSNAC) FOR UP-REGULATION OF CELLULAR GLUTATHIONE LEVEL | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2008-11-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120295977-A1 | Organosulfur prodrugs for the prevention and treatment of infectious diseases | TST, AHCY, MPST | MAPT 3906/4885ALOX15 599/4885KDM4E 4533/4885 |
| US-20190076377-A1 | ORGANOSULFUR COMPOUNDS FOR THE PREVENTION AND TREATMENT OF NEURODEGENERATIVE DISEASES | SNCA, PARK7, TST | MAPT 49/4885ALOX15 374/4885KDM4E 4177/4885 |
| US-20130143967-A1 | Organosulfur compounds for the prevention and treatment of neurodegenerative diseases | SNCA, PARK7, TST | MAPT 80/4885ALOX15 306/4885KDM4E 3942/4885 |
| US-20110178152-A1 | COMPOSITION COMPRISING S-ALLYLMERCAPTO-N-ACETYLCYSTEINE (ASSNAC) FOR UP-REGULATION OF CELLULAR GLUTATHIONE LEVEL | GSTP1, GSTA1, GSTO1 | MAPT 1768/4885ALOX15 417/4885KDM4E 4812/4885 |
| US-20130165515-A1 | Organosulfur Compounds for the Prevention and Treatment of Neurodegenerative Diseases | SNCA, PARK7, TST | MAPT 49/4885ALOX15 374/4885KDM4E 4177/4885 |
| US-10758498-B2 | Method of decreasing protein-aldehyde adducts by administering a mixed disulfide of n-acetylcysteine and propyl mercaptan, propenyl mercaptan, or allyl mercaptan | SNCA, PARK7, MGMT | MAPT 114/4885ALOX15 574/4885KDM4E 4516/4885 |
| US-10258581-B2 | Organosulfur compounds for the prevention and treatment of neurodegenerative diseases | SNCA, PARK7, TST | MAPT 49/4885ALOX15 374/4885KDM4E 4177/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.