SCHEMBL2224441

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL2226396	0.92	CCR5 (0.40)	OPRK1UBE2MDCUN1D1KDM4EALDH1A1
	SCHEMBL2224017	0.88	SLC6A2 (0.38)	NAMPTOPRK1AAK1CCR5
	SCHEMBL2221367	0.86	THRB (0.41)	UBE2MDCUN1D1KDM4EALDH1A1CCR5
	SCHEMBL2223104	0.86	CCR5 (0.39)	OPRK1UBE2MDCUN1D1KDM4EALDH1A1
	SCHEMBL2223638	0.86	OPRK1 (0.35)	OPRK1KDM4EAAK1CCR5TRPM8
	SCHEMBL2221583	0.86	HTR2A (0.38)	OPRK1ACACB
	SCHEMBL2222776	0.86	L3MBTL1 (0.39)	UBE2MDCUN1D1KDM4EALDH1A1CCR5
	SCHEMBL2223593	0.85	SLC6A9 (0.36)	OPRK1UBE2MDCUN1D1KDM4ECCR5
	SCHEMBL2222845	0.85	KDM4E (0.39)	UBE2MDCUN1D1KDM4ECCR5
	SCHEMBL2224420	0.85	HTR2A (0.39)	ACACB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.