SCHEMBL22260360

SCHEMBL22260360

CC(C)n1ccn2c(=O)[nH]c(=O)nc12

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.30
ALDH1A1 P00352 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19286497 0.72 L3MBTL1 (0.33) KDM4EALDH1A1
SCHEMBL6020610 0.69 CDK1 (0.39)
SCHEMBL10101240 0.68 ALDH1A1 (0.36) ALDH1A1
SCHEMBL25467593 0.66 PTPN2 (0.46) KDM4EALDH1A1
SCHEMBL18289528 0.62 CDK2 (0.54) KDM4E
SCHEMBL12617157 0.61
SCHEMBL12128675 0.60 ADORA2B (0.31)
SCHEMBL22071854 0.60 ADORA3 (0.33)
SCHEMBL12565954 0.59
SCHEMBL21126208 0.59 CDK1 (0.50) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200231620-A1 TECHNOLOGIES FOR OLIGONUCLEOTIDE PREPARATION WAVE LIFE SCIENCES LTD. (SG) 2020-07-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200231620-A1 TECHNOLOGIES FOR OLIGONUCLEOTIDE PREPARATION POLRMT, DCLRE1B, RNGTT KDM4E 3297/4885ALDH1A1 3318/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.