SCHEMBL22263190

SCHEMBL22263190

COC(=O)CNC(=O)c1snc(Cl)c1Cl

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.43
GAA P10253 1/20 0.43
HSD17B10 Q99714 2/20 0.39
MAPK1 P28482 2/20 0.39
ALDH1A1 P00352 2/20 0.39
HPGD P15428 1/20 0.39
HTT P42858 1/20 0.39
EGLN1 Q9GZT9 3/20 0.38
GLA P06280 1/20 0.38
PKM P14618 1/20 0.38
TET2 Q6N021 1/20 0.37
SMN1; SMN2 Q16637 2/20 0.36
MEN1 O00255 1/20 0.36
TSHR P16473 1/20 0.36
KMT2A Q03164 1/20 0.36
RECQL P46063 1/20 0.36
VEGFA P15692 2/20 0.36
FLT1 P17948 2/20 0.36
EGLN3 Q9H6Z9 2/20 0.36
L3MBTL1 Q9Y468 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7088428 0.83 ALDH1A1 (0.42) KDM4EGAAHSD17B10MAPK1ALDH1A1
SCHEMBL7084982 0.82 ALDH1A1 (0.34) KDM4EHSD17B10MAPK1ALDH1A1HPGD
SCHEMBL3566444 0.80 LMNA (0.42) KDM4EGAAHSD17B10MAPK1ALDH1A1
SCHEMBL7084526 0.78 ALDH1A1 (0.34) KDM4EHSD17B10MAPK1ALDH1A1HPGD
SCHEMBL22279522 0.76 KDM4E (0.44) KDM4EGAAHSD17B10MAPK1ALDH1A1
SCHEMBL7073731 0.76 ALDH1A1 (0.37) KDM4EHSD17B10MAPK1ALDH1A1HPGD
SCHEMBL13515535 0.76 ALDH1A1 (0.42) KDM4EGAAHSD17B10MAPK1ALDH1A1
SCHEMBL7085349 0.74 OGG1 (0.41) KDM4EGAAMAPK1ALDH1A1HTT
SCHEMBL7088346 0.74 SMN1; SMN2 (0.38) KDM4EGAAALDH1A1HPGDHTT
SCHEMBL6750239 0.74 KMT2A (0.41) KDM4EHSD17B10MAPK1ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200236935-A1 a-Amino Acrylate microbicide, and preparation method therefor and uses thereof UNIV NANKAI (CN) 2020-07-30 US claimed
CN-111362933-A α -amino acrylic acid microbicide and preparation method and application thereof 南开大学 2020-07-03 CN claimed
US-11166460-B2 α-amino acrylate microbicide, and preparation method therefor and uses thereof NANKAI UNIVERSITY (CN) 2021-11-09 US disclosed
US-20200236935-A1 a-Amino Acrylate microbicide, and preparation method therefor and uses thereof UNIV NANKAI (CN) 2020-07-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200236935-A1 a-Amino Acrylate microbicide, and preparation method therefor and uses thereof AASDHPPT, ACE, ADA KDM4E 1158/4885GAA 431/4885HSD17B10 3965/4885
US-11166460-B2 α-amino acrylate microbicide, and preparation method therefor and uses thereof ACE, AASDHPPT, DDT KDM4E 1290/4885GAA 406/4885HSD17B10 3945/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.