SCHEMBL22281036

SCHEMBL22281036

CO[C@@H](Cc1cccc(Br)c1)C(=O)O

nearest known ligand 0.49

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ SRR Q9GZT4 2/20 0.49
▸ PPARA Q07869 10/20 0.47
▸ PPARG P37231 9/20 0.47
▸ PPARD Q03181 4/20 0.47
▸ FFAR1 O14842 1/20 0.45
▸ HCAR2 Q8TDS4 1/20 0.44
▸ MAOB P27338 2/20 0.44
▸ MAOA P21397 1/20 0.44
▸ PTGES O14684 1/20 0.44
▸ CTSB P07858 1/20 0.44
▸ CTSS P25774 1/20 0.44
▸ CTSK P43235 1/20 0.44
▸ IDO1 P14902 1/20 0.44
▸ AGXT P21549 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5383259 0.83 SRR (0.50) SRRPPARAPPARGPPARDFFAR1
SCHEMBL22264856 0.83 PPARG (0.56) SRRPPARAPPARGPPARDFFAR1
SCHEMBL22264858 0.83 PPARG (0.56) SRRPPARAPPARGPPARDFFAR1
SCHEMBL31321016 0.83 PPARG (0.56) SRRPPARAPPARGPPARDFFAR1
SCHEMBL9628212 0.81 SRR (0.70) SRRPPARAPPARGPPARD
SCHEMBL2517934 0.81 SRR (0.70) SRRPPARAPPARGPPARD
SCHEMBL16877217 0.81 SRR (0.70) SRRPPARAPPARGPPARD
SCHEMBL23933856 0.81 PPARA (0.54) SRRPPARAPPARGPPARD
SCHEMBL757308 0.81 SRR (0.53) SRRPPARAPPARGPPARDFFAR1
SCHEMBL23933859 0.81 PPARA (0.54) SRRPPARAPPARGPPARD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11773101-B2 GPR35 modulators PROMETHEUS BIOSCIENCES, INC. (US) 2023-10-03 — — US disclosed
US-11773101-B2 GPR35 modulators PROMETHEUS BIOSCIENCES, INC. (US) 2023-10-03 — — US disclosed
WO-2020154492-A1 GPR35 MODULATORS PROMETHEUS BIOSCIENCES, INC. (US) 2020-07-30 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11773101-B2 GPR35 modulators GPR35, GPR55, GPR65 SRR 3009/4885PPARA 87/4885PPARG 34/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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