SCHEMBL757308

SCHEMBL757308

COC(Cc1cccc(N)c1)C(=O)O

nearest known ligand 0.53

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
SRR Q9GZT4 3/20 0.53
FFAR1 O14842 1/20 0.47
PPARG P37231 10/20 0.47
PPARA Q07869 10/20 0.47
PPARD Q03181 4/20 0.47
SLC7A5 Q01650 2/20 0.47
MAOA P21397 2/20 0.46
MAOB P27338 2/20 0.46
PLA2G10 O15496 1/20 0.44
PLA2G2A P14555 1/20 0.44
PLA2G5 P39877 1/20 0.44
PSAT1 Q9Y617 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1094834 1.00 SRR (0.53) SRRFFAR1PPARGPPARAPPARD
SCHEMBL1094835 1.00 SRR (0.53) SRRFFAR1PPARGPPARAPPARD
SCHEMBL15679980 1.00 SRR (0.53) SRRFFAR1PPARGPPARAPPARD
SCHEMBL756254 0.85 PPARG (0.57) PPARGPPARAPPARD
SCHEMBL28748038 0.85 SRR (0.47) SRRPPARGPPARASLC7A5
SCHEMBL1105056 0.84 MAOB (0.46) SRRSLC7A5MAOAMAOB
SCHEMBL5383259 0.83 SRR (0.50) SRRFFAR1PPARGPPARAPPARD
SCHEMBL31321016 0.83 PPARG (0.56) SRRFFAR1PPARGPPARAPPARD
SCHEMBL22264856 0.83 PPARG (0.56) SRRFFAR1PPARGPPARAPPARD
SCHEMBL22264858 0.83 PPARG (0.56) SRRFFAR1PPARGPPARAPPARD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 100 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9561202-B2 Compounds and their salts specific to the PPAR receptors and the EGF receptors and their use in the medical field NOGRA PHARMA LIMITED (IE) 2017-02-07 US claimed
US-20150265562-A1 Compounds and their Salts Specific to the PPAR Receptors and the EGF Receptors and their Use in the Medical Field GIULIANI INTERNATIONAL LIMITED (IE) 2015-09-24 US claimed
US-20150045436-A1 Compounds and their Salts Specific to the PPAR Receptors and the EGF Receptors and their Use in the Medical Field NOGRA PHARMA LIMITED (IE) 2015-02-12 US claimed
US-8710100-B2 Compounds and their salts specific to the PPAR receptors and the EGF receptors and their use in the medical field NOGRA PHARMA LIMITED (IE) 2014-04-29 US claimed
EP-1910270-B1 COMPOUNDS AND THEIR SALTS SPECIFIC TO THE PPAR RECEPTORS AND THE EGF RECEPTORS AND THEIR USE IN THE MEDICAL FIELD NOGRA PHARMA LTD (IE) 2013-05-08 EP claimed
US-20130005813-A1 Compounds and their Salts Specific to the PPAR Receptors and the EGF Receptors and their Use in the Medical Field GIULIANI INTERNATIONAL LIMITED (IE) 2013-01-03 US claimed
US-8153693-B2 Compounds for the selective treatment of the intestinal immuno-inflammatory component of the celiac disease GIULIANI INTERNATIONAL LIMITED (IE) 2012-04-10 US claimed
EP-2222291-B1 COMPOUNDS FOR THE SELECTIVE TREATMENT OF THE INTESTINAL IMMUNO-INFLAMMATORY COMPONENT OF THE CELIAC DISEASE GIULIANI INT LTD (IE) 2012-03-21 EP claimed
US-20110152225-A1 PPAR-Gamma Agonists for the Induction of Cationic Antimicrobial Peptide Expression as Immunoprotective Stimulants NOGRA PHARMA LIMITED (IE) 2011-06-23 US claimed
US-20100305077-A1 COMPOUNDS FOR THE SELECTIVE TREATMENT OF THE INTESTINAL IMMUNO-INFLAMMATORY COMPONENT OF THE CELIAC DISEASE NOGRA PHARMA LIMITED (IE) 2010-12-02 US claimed
EP-2131829-A1 PPAR-GAMMA AGONISTS FOR THE INDUCTION OF CATIONIC ANTIMICROBIAL PEPTIDE EXPRESSION AS IMMUNOPROTECTIVE STIMULANTS Giuliani International Limited (IE) 2009-12-16 EP claimed
US-20090048343-A1 Compounds and Their Salts Specific to the PPAR Receptors and the EGF Receptors and Their Use in the Medical Field NOGRA PHARMA LIMITED (IE) 2009-02-19 US claimed
WO-2008104557-A1 PPAR-GAMMA AGONISTS FOR THE INDUCTION OF CATIONIC ANTIMICROBIAL PEPTIDE EXPRESSION AS IMMUNOPROTECTIVE STIMULANTS GIULIANI INTERNATIONAL LIMITED (IE) 2008-09-04 WO claimed
EP-1910270-A2 COMPOUNDS AND THEIR SALTS SPECIFIC TO THE PPAR RECEPTORS AND THE EGF RECEPTORS AND THEIR USE IN THE MEDICAL FIELD Giuliani International Limited (IE) 2008-04-16 EP claimed
WO-2007010516-A2 COMPOUNDS AND THEIR SALTS SPECIFIC TO THE PPAR RECEPTORS AND THE EGF RECEPTORS AND THEIR USE IN THE MEDICAL FIELD GIULIANI INTERNATIONAL LIMITED (IE) 2007-01-25 WO claimed
US-11753365-B2 Methods of treating fibrosis NOGRA PHARMA LIMITED (IE) 2023-09-12 US disclosed
US-20220033346-A1 METHODS OF TREATING FIBROSIS NOGRA PHARMA LIMITED (IE) 2022-02-03 US disclosed
US-4522839-A 3-Substituted 2,4,6-trihalogenated benzamides as sweetening agents SCHERING AKTIENGESELLSCHAFT (DE) 1985-06-11 US disclosed
EP-0055689-B1 3-SUBSTITUTED 2,4,6-TRIHALOGENOBENZAMIDES AND THEIR SALTS, THEIR PREPARATION AND THEIR USE AS SUBSTITUTES FOR NATURAL SWEETENING AGENTS, AND SWEETENERS CONTAINING THEM SCHERING AKTIENGESELLSCHAFT (DE) 1984-07-04 EP disclosed
US-4429152-A DIABETES, DIETETICS SCHERING, AKTIENGESELLSCHAFT (DE) 1984-01-31 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100305077-A1 COMPOUNDS FOR THE SELECTIVE TREATMENT OF THE INTESTINAL IMMUNO-INFLAMMATORY COMPONENT OF THE CELIAC DISEASE SI, FABP2, NFKBIA SRR 451/4885FFAR1 2685/4885PPARG 838/4885
US-20150265562-A1 Compounds and their Salts Specific to the PPAR Receptors and the EGF Receptors and their Use in the Medical Field EGFR, ERBB3, FGFR3 SRR 1855/4885FFAR1 55/4885PPARG 4/4885
US-11753365-B2 Methods of treating fibrosis MMP1, MMP8, FABP2 SRR 3600/4885FFAR1 2768/4885PPARG 669/4885
US-20090048343-A1 Compounds and Their Salts Specific to the PPAR Receptors and the EGF Receptors and Their Use in the Medical Field EGFR, ERBB3, FGFR3 SRR 1855/4885FFAR1 55/4885PPARG 4/4885
US-20150045436-A1 Compounds and their Salts Specific to the PPAR Receptors and the EGF Receptors and their Use in the Medical Field EGFR, ERBB3, FGFR3 SRR 1596/4885FFAR1 56/4885PPARG 4/4885
US-20130005813-A1 Compounds and their Salts Specific to the PPAR Receptors and the EGF Receptors and their Use in the Medical Field EGFR, ERBB3, FGFR3 SRR 1855/4885FFAR1 55/4885PPARG 4/4885
US-20110152225-A1 PPAR-Gamma Agonists for the Induction of Cationic Antimicrobial Peptide Expression as Immunoprotective Stimulants PPARG, FABP2, PPARD SRR 1693/4885FFAR1 87/4885PPARG 1/4885
US-20220033346-A1 METHODS OF TREATING FIBROSIS MMP1, MMP8, FABP2 SRR 3600/4885FFAR1 2768/4885PPARG 669/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.