Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 10/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 10/20 | 0.45 |
| ▸ | CHRNB4 | P30926 | 8/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 8/20 | 0.44 |
| ▸ | LCAT | P04180 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22340525 | 0.84 | HTR2C (0.53) | ROCK2 | |
| SCHEMBL22324868 | 0.83 | DRD2 (0.49) | HRH4HRH3 | |
| SCHEMBL22324859 | 0.82 | ROCK2 (0.44) | ROCK2 | |
| SCHEMBL22324882 | 0.79 | LCAT (0.40) | LCATROCK2HRH4HRH3 | |
| SCHEMBL22324818 | 0.78 | CHRNB2 (0.43) | CHRNB2CHRNA4CHRNB4CHRNA3LCAT | |
| SCHEMBL22324940 | 0.76 | TLR9 (0.41) | ROCK2 | |
| SCHEMBL22325001 | 0.74 | CHRNB2 (0.45) | CHRNB2CHRNA4CHRNB4CHRNA3LCAT | |
| SCHEMBL22324896 | 0.74 | SLC18A3 (0.41) | ROCK2 | |
| SCHEMBL22340466 | 0.74 | DHFR (0.46) | ROCK2 | |
| SCHEMBL4881754 | 0.73 | HTR2C (0.59) | CHRNB2CHRNA4CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12479816-B2 | 20-HETE formation inhibitors | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2025-11-25 | — | — | US | disclosed |
| US-20220144797-A1 | 20-HETE FORMATION INHIBITORS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2022-05-12 | — | — | US | disclosed |
| US-20220144797-A1 | 20-HETE FORMATION INHIBITORS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2022-05-12 | — | — | US | disclosed |
| WO-2020163689-A1 | 20-HETE FORMATION INHIBITORS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-08-13 | — | — | WO | disclosed |
| WO-2020163689-A1 | 20-HETE FORMATION INHIBITORS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-08-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220144797-A1 | 20-HETE FORMATION INHIBITORS | CYP4A22, ALOX5, ALOX15 | CHRNB2 1365/4885CHRNA4 727/4885CHRNB4 574/4885 |
| US-12479816-B2 | 20-HETE formation inhibitors | CYP4A22, ALOX5, ALOX15 | CHRNB2 1365/4885CHRNA4 727/4885CHRNB4 574/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.